Phenotypes associated with this allele

• Allele Symbol: Sod1^tm1Ysh
• Allele Name: targeted mutation 1, Ye-Shih Ho
• Allele ID: MGI:3526701
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sod1^tm1Ysh/Sod1^tm1Ysh	involves: 129X1/SvJ * C57BL/6	MGI:3526735

Genotype
MGI:3526735

hm1

• Allelic Composition: Sod1^tm1Ysh/Sod1^tm1Ysh
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:46672 )

• median survival time following 10 mg/kg paraquat exposure is 1.4 days in contrast wild-type and heterozygous mice exposed to the same concentration all survive

reproductive system

reduced female fertility ( J:46672 )

♀ • fewer litters result per mating are seen in mutant females however male fertility is normal

♀ • homozygous females have a higher rate of post-implantation embryonic death that is dependent on the maternal genotype, however estrus cycle and ovarian morphology are normal

decreased litter size ( J:46672 )

behavior/neurological

enhanced behavioral response to xenobiotic ( J:46672 )

• mutants become listless within about 30 minutes of intraperitoneal paraquat exposure (10 mg/kg), no such effect is seen in wild-type or heterozygous mice

homeostasis/metabolism

increased susceptibility to xenobiotic induced morbidity/mortality ( J:46672 )

• median survival time following 10 mg/kg paraquat exposure is 1.4 days in contrast wild-type and heterozygous mice exposed to the same concentration all survive