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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Igh-6/Igh-V125)2Jwt
transgene insertion 2, James W Thomas
MGI:3526723
Summary 3 genotypes


Genotype
MGI:3623594
cx1
Allelic
Composition		 Tg(Igh-6/Igh-V125)2Jwt/0
Tg(Igk-C/Igk-V125)1Jwt/0
Genetic
Background		 NOD.B6-Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Igh-6/Igh-V125)2Jwt mutation (1 available)
Tg(Igk-C/Igk-V125)1Jwt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
insulitis ( J:91865 )
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates

immune system
insulitis ( J:91865 )
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates
abnormal B cell number ( J:91865 )
• V125 transgene-carrying mice have more B220+ cells that bind insulin compared to NOD controls or V281 transgene-carrying mice
increased susceptibility to autoimmune diabetes ( J:91865 )
• transgenic females develop diabetes (2 consecutive blood glucose measurements >200 mg/dl) at an accelerated rate; 95% develop diabetes by 40 weeks

hematopoietic system
abnormal B cell number ( J:91865 )
• V125 transgene-carrying mice have more B220+ cells that bind insulin compared to NOD controls or V281 transgene-carrying mice

homeostasis/metabolism
increased circulating glucose level ( J:91865 )
• mice are diabetic if 2 consecutive blood glucose measurements are >200 mg/dl

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:91865




Genotype
MGI:3623595
cx2
Allelic
Composition		 Ighmtm1Cgn/Ighmtm1Cgn
Tg(Igh-6/Igh-V125)2Jwt/0
Tg(Igk-C/Igk-V125)1Jwt/0
Genetic
Background		 NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Cgn mutation (17 available); any Ighm mutation (56 available)
Tg(Igh-6/Igh-V125)2Jwt mutation (1 available)
Tg(Igk-C/Igk-V125)1Jwt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
insulitis ( J:91865 )
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates; at 6 weeks, in the early prediabetic period, the incidence of infiltration is 40-50%

immune system
insulitis ( J:91865 )
• by 40 weeks, pancreata of transgenic mice show extensive infiltrates; at 6 weeks, in the early prediabetic period, the incidence of infiltration is 40-50%




Genotype
MGI:3623596
cx3
Allelic
Composition		 Ighmtm1Cgn/Ighm+
Tg(Igh-6/Igh-V125)2Jwt/0
Tg(Igk-C/Igk-V125)1Jwt/0
Genetic
Background		 NOD.Cg-Ighmtm1Cgn Tg(Igh-6/Igh-V125)2Jwt Tg(Igk-C/Igk-V125)1Jwt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1Cgn mutation (17 available); any Ighm mutation (56 available)
Tg(Igh-6/Igh-V125)2Jwt mutation (1 available)
Tg(Igk-C/Igk-V125)1Jwt mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
insulitis ( J:91865 )
• the percentage of islets infiltrated is slightly increased in Igh-6-heterozygous transgenic mice

immune system
insulitis ( J:91865 )
• the percentage of islets infiltrated is slightly increased in Igh-6-heterozygous transgenic mice
increased susceptibility to autoimmune diabetes ( J:91865 )
• transgenic females heterozygous for Igh-6 develop diabetes (2 consecutive blood glucose measurements >200 mg/dl) at a slightly earlier time (12 weeks) than homozygous transgenic females but the incidence is the same by 17 weeks

homeostasis/metabolism




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Send questions and comments to User Support. 		last database update
12/10/2024
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