Phenotypes associated with this allele

• Allele Symbol: Cx3cl1^tm1Sgs
• Allele Name: targeted mutation 1, Sulpicio G Soriano
• Allele ID: MGI:3526846
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cx3cl1^tm1Sgs/Cx3cl1^tm1Sgs	involves: 129S4/SvJae	MGI:3527868
cx2	Apoe^tm1Unc/Apoe^tm1Unc Cx3cl1^tm1Sgs/Cx3cl1^tm1Sgs	B6.129-Apoe^tm1Unc Cx3cl1^tm1Sgs	MGI:3527869
cx3	Cx3cl1^tm1Sgs/Cx3cl1^tm1Sgs Ldlr^tm1Her/Ldlr^tm1Her	involves: B6.129S4-Cx3cl1^tm1Sgs * B6.129S7-Ldlr^tm1Her/J	MGI:3527874
cx4	Cx3cl1^tm1Sgs/Cx3cl1^tm1Sgs Ldlr^tm1Her/Ldlr^+	involves: B6.129S4-Cx3cl1^tm1Sgs * B6.129S7-Ldlr^tm1Her/J	MGI:3527876

Genotype
MGI:3527868

hm1

• Allelic Composition: Cx3cl1^tm1Sgs/Cx3cl1^tm1Sgs
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased cerebral infarct size ( J:95634 )

• infarct size was reduced by 28% and significantly lower mortality was seen in homozygotes compared to wild-type mice after middle cerebral artery occlusion

• however, the brain and surface cerebral arteries are not significantly different in homozygotes compared to wild-type mice

homeostasis/metabolism

decreased cerebral infarct size ( J:95634 )

• infarct size was reduced by 28% and significantly lower mortality was seen in homozygotes compared to wild-type mice after middle cerebral artery occlusion

• however, the brain and surface cerebral arteries are not significantly different in homozygotes compared to wild-type mice

Genotype
MGI:3527869

cx2

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Cx3cl1^tm1Sgs/Cx3cl1^tm1Sgs
• Genetic Background: B6.129-Apoe^tm1Unc Cx3cl1^tm1Sgs

cardiovascular system

decreased susceptibility to atherosclerosis ( J:95279 )

• brachiocephalic artery lesion area is reduced by about 85% at 200 um and 400 um but not at 600 um from its branching site into the carotid and subclavian arteries in female double homozygotes compared to Apoe single homozygotes

• in male double homozygotes brachiocephalic artery lesion area is reduced by 82% at 200 um, 58% at 400 um, and 59% at 600 um

• aortic root lesion area is reduced by about 30% in double homozygous females at 12 weeks of age but not in males at 12 weeks or in either sex at 16 weeks

• lesions are less advanced than in Apoe single homozygotes and are composed almost entirely of foam cells

immune system

increased macrophage derived foam cell number ( J:95279 )

• atherosclerotic lesions are composed almost entirely of foam cells

impaired macrophage chemotaxis ( J:95279 )

• macrophage accumulation is reduced by 80% in the brachiocephalic artery at 200 um from its branching site into the carotid and subclavian arteries

hematopoietic system

increased macrophage derived foam cell number ( J:95279 )

• atherosclerotic lesions are composed almost entirely of foam cells

impaired macrophage chemotaxis ( J:95279 )

• macrophage accumulation is reduced by 80% in the brachiocephalic artery at 200 um from its branching site into the carotid and subclavian arteries

cellular

increased macrophage derived foam cell number ( J:95279 )

• atherosclerotic lesions are composed almost entirely of foam cells

impaired macrophage chemotaxis ( J:95279 )

• macrophage accumulation is reduced by 80% in the brachiocephalic artery at 200 um from its branching site into the carotid and subclavian arteries

Genotype
MGI:3527874

cx3

• Allelic Composition: Cx3cl1^tm1Sgs/Cx3cl1^tm1Sgs; Ldlr^tm1Her/Ldlr^tm1Her
• Genetic Background: involves: B6.129S4-Cx3cl1^tm1Sgs * B6.129S7-Ldlr^tm1Her/J

cardiovascular system

decreased susceptibility to atherosclerosis ( J:95279 )

• aortic-root lesion area is reduced in females by 35% but not reduced in males

• brachiocephalic artery lesion area is reduced in female double homozygotes by about 50% at 200 um from its branching site into the carotid and subclavian arteries

homeostasis/metabolism

decreased circulating cholesterol level ( J:95279 )

• the decrease in total serum cholesterol is mainly due to a decrease in LDL cholesterol

decreased circulating LDL cholesterol level ( J:95279 )

immune system

impaired macrophage chemotaxis ( J:95279 )

• macrophage accumulation is reduced by 57% in the brachiocephalic artery at 200 um from its branching site into the carotid and subclavian arteries

cellular

impaired macrophage chemotaxis ( J:95279 )

• macrophage accumulation is reduced by 57% in the brachiocephalic artery at 200 um from its branching site into the carotid and subclavian arteries

hematopoietic system

impaired macrophage chemotaxis ( J:95279 )

• macrophage accumulation is reduced by 57% in the brachiocephalic artery at 200 um from its branching site into the carotid and subclavian arteries

Genotype
MGI:3527876

cx4

• Allelic Composition: Cx3cl1^tm1Sgs/Cx3cl1^tm1Sgs; Ldlr^tm1Her/Ldlr⁺
• Genetic Background: involves: B6.129S4-Cx3cl1^tm1Sgs * B6.129S7-Ldlr^tm1Her/J

cardiovascular system

decreased susceptibility to atherosclerosis ( J:95279 )

• aortic-root lesion area is reduced in females by 28% but not reduced in males

homeostasis/metabolism

decreased circulating cholesterol level ( J:95279 )

• total serum cholesterol is reduced in male but not female mutants

decreased circulating LDL cholesterol level ( J:95279 )