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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Krt90whnl
witch nails
MGI:3526848
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Krt90whnl/Krt90whnl B6.MRL-Krt90whnl/GrsrJ MGI:5649155
hm2
 		Krt90whnl/Krt90whnl involves: MRL/MpJ MGI:5649153


Genotype
MGI:5649155
hm1
Allelic
Composition		 Krt90whnl/Krt90whnl
Genetic
Background		 B6.MRL-Krt90whnl/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt90whnl mutation (1 available); any Krt90 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
long toenails ( J:223505 )
• all homozygotes develop very long nails on all digits by 2 months of age and although the nail bed is normal the nail is thickened and elongated

mortality/aging
prenatal lethality, incomplete penetrance ( J:223505 )
• fewer than 10 percent of offspring from heterozgyous intercrosses were homozygotes

limbs/digits/tail
long toenails ( J:223505 )
• all homozygotes develop very long nails on all digits by 2 months of age and although the nail bed is normal the nail is thickened and elongated




Genotype
MGI:5649153
hm2
Allelic
Composition		 Krt90whnl/Krt90whnl
Genetic
Background		 involves: MRL/MpJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt90whnl mutation (1 available); any Krt90 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Rear paw of Krt90whnl/Krt90whnl mouse showing very long nails

integument
long toenails ( J:223505 )
• all homozygotes develop very long nails on all digits by 2 months of age and although the nail bed is normal the nail is thickened and elongated

mortality/aging
prenatal lethality, incomplete penetrance ( J:223505 )
• fewer than 10 percent of offspring from heterozgyous intercrosses were homozygotes

vision/eye
vision/eye phenotype ( J:223505 )
N
• ophthalmoscopic examination of the eyes of 2 homozygotes at 4 months of age found no abnormality

hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:223505 )
N
• ABR threshold assessment on 2 homozygotes at 4 months of age found no abnormality

limbs/digits/tail
long toenails ( J:223505 )
• all homozygotes develop very long nails on all digits by 2 months of age and although the nail bed is normal the nail is thickened and elongated
increased caudal vertebrae number ( J:223505 )
• X-rays of 5 homozogytes showed additional caudal vertebrae in some but not all mutants

skeleton
increased caudal vertebrae number ( J:223505 )
• X-rays of 5 homozogytes showed additional caudal vertebrae in some but not all mutants




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory