All Phenotypes Arid5b<Gt(ROSA)75Sor> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor}	involves: 129S4/SvJaeSor	MGI:3717110
cx2	Zfp950^{Gt(ROSA)76Sor}/Zfp950^{Gt(ROSA)76Sor} Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor}	involves: 129S4/SvJaeSor	MGI:3717128
cx3	Zfp950^{Gt(ROSA)76Sor}/Zfp950⁺ Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor}	involves: 129S4/SvJaeSor	MGI:3717130
cx4	Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Pdgfra^tm2Sor/Pdgfra⁺	involves: 129S4/SvJaeSor	MGI:3717132

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:117491 )

• 46% of mice die by 3 weeks

skeleton

abnormal skeleton morphology ( J:117491 )

• abnormal neural crest derived and thoracic skeleton

abnormal neurocranium morphology ( J:117491 )

• 43% of mice have reduced calvarial bones at the midline with increases in the gaps between frontal bones

abnormal frontal bone morphology ( J:117491 )

• increases in the gaps between frontal bones

small presphenoid bone ( J:117491 )

• all homozygous mice have smaller presphenoid bone processes that are less extended towards the midline

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

decreased palatine bone horizontal plate size ( J:117491 )

• all homozygous mice have smaller palatine bone processes that are less extended towards the midline

abnormal sternum morphology ( J:117491 )

• 43% of mice have sternum defects including asymmetric or additional fusion of ribs and gaps in the sternum

asymmetric sternocostal joints ( J:117491 )

abnormal vertebrae morphology ( J:117491 )

• 43% of mice have widened vertebral arches and forked vertebrae

abnormal vertebral arch morphology ( J:117491 )

• 43% of mice have widened vertebral arches and forked vertebrae

renal/urinary system

abnormal kidney morphology ( J:117491 )

abnormal renal glomerulus morphology ( J:117491 )

• glomeruli are often degraded

• smooth muscle cell number is reduced in the glomeruli

• migration of smooth muscle cells in glomeruli is impaired

small kidney ( J:117491 )

pale kidney ( J:117491 )

abnormal kidney physiology ( J:117491 )

• decrease in kidney function

kidney inflammation ( J:117491 )

• kidney is swollen in sections and blood filled

growth/size/body

short nasal bone ( J:117491 )

abnormal palate morphology ( J:117491 )

• irregularities in fusion persist into adulthood

decreased palatine bone horizontal plate size ( J:117491 )

• all homozygous mice have smaller palatine bone processes that are less extended towards the midline

broad snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

short snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

decreased body weight ( J:117491 )

postnatal growth retardation ( J:117491 )

homeostasis/metabolism

increased blood urea nitrogen level ( J:117491 )

muscle

abnormal smooth muscle morphology ( J:117491 )

• smooth muscle cell number is reduced in the glomeruli

cellular

abnormal cell migration ( J:117491 )

• migration of smooth muscle cells in glomeruli is impaired

decreased fibroblast cell migration ( J:117491 )

• mouse embryonic fibroblast cells show reduced migration in a scratch test in response to PDGF stimulation

immune system

kidney inflammation ( J:117491 )

• kidney is swollen in sections and blood filled

craniofacial

abnormal neurocranium morphology ( J:117491 )

• 43% of mice have reduced calvarial bones at the midline with increases in the gaps between frontal bones

abnormal frontal bone morphology ( J:117491 )

• increases in the gaps between frontal bones

small presphenoid bone ( J:117491 )

• all homozygous mice have smaller presphenoid bone processes that are less extended towards the midline

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

abnormal palate morphology ( J:117491 )

• irregularities in fusion persist into adulthood

decreased palatine bone horizontal plate size ( J:117491 )

• all homozygous mice have smaller palatine bone processes that are less extended towards the midline

broad snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

short snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

digestive/alimentary system

abnormal palate morphology ( J:117491 )

• irregularities in fusion persist into adulthood

decreased palatine bone horizontal plate size ( J:117491 )

• all homozygous mice have smaller palatine bone processes that are less extended towards the midline

respiratory system

short nasal bone ( J:117491 )

Allelic Composition	Zfp950^{Gt(ROSA)76Sor}/Zfp950^{Gt(ROSA)76Sor} Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor}
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid5b^{Gt(ROSA)75Sor} mutation (1 available); any Arid5b mutation (136 available)
Zfp950^{Gt(ROSA)76Sor} mutation (1 available); any Zfp950 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:117491 )

• mice die within hours of birth

skeleton

abnormal skeleton morphology ( J:117491 )

• skeletal defects are more severe than in single transgenic

absent palatine bone horizontal plate ( J:117491 )

• near-absence of the palatin process in 4 of 5 mice

craniofacial

absent palatine bone horizontal plate ( J:117491 )

• near-absence of the palatin process in 4 of 5 mice

cleft palate ( J:117491 )

• partial or full cleft

digestive/alimentary system

absent palatine bone horizontal plate ( J:117491 )

• near-absence of the palatin process in 4 of 5 mice

cleft palate ( J:117491 )

• partial or full cleft

growth/size/body

absent palatine bone horizontal plate ( J:117491 )

• near-absence of the palatin process in 4 of 5 mice

cleft palate ( J:117491 )

• partial or full cleft

Allelic Composition	Zfp950^{Gt(ROSA)76Sor}/Zfp950⁺ Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor}
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

broad snout ( J:117491 )

• wider snouts than in either single homozygous transgenic mouse

growth/size/body

short nasal bone ( J:117491 )

broad snout ( J:117491 )

• wider snouts than in either single homozygous transgenic mouse

decreased body height ( J:117491 )

• shorter than in either single homozygous transgenic mouse

skeleton

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

respiratory system

short nasal bone ( J:117491 )

Allelic Composition	Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor} Pdgfra^tm2Sor/Pdgfra⁺
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid5b^{Gt(ROSA)75Sor} mutation (1 available); any Arid5b mutation (136 available)
Pdgfra^tm2Sor mutation (0 available); any Pdgfra mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with Arid5b^{Gt(ROSA)75Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

cleft palate ( J:117491 )

• reduced or completely cleft palates are present in all mice

complete cleft palate ( J:117491 )

broad snout ( J:117491 )

• snout is shorter and wider than in Arid5b^{Gt(ROSA)75Sor} homozygotes

short snout ( J:117491 )

• snout is shorter and wider than in Arid5b^{Gt(ROSA)75Sor} homozygotes

skeleton

abnormal skeleton morphology ( J:117491 )

• skeletal defects are more severe than in Arid5b^{Gt(ROSA)75Sor} homozygotes

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with Arid5b^{Gt(ROSA)75Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

digestive/alimentary system

cleft palate ( J:117491 )

• reduced or completely cleft palates are present in all mice

complete cleft palate ( J:117491 )

growth/size/body

short nasal bone ( J:117491 )

cleft palate ( J:117491 )

• reduced or completely cleft palates are present in all mice

complete cleft palate ( J:117491 )

broad snout ( J:117491 )

• snout is shorter and wider than in Arid5b^{Gt(ROSA)75Sor} homozygotes

short snout ( J:117491 )

• snout is shorter and wider than in Arid5b^{Gt(ROSA)75Sor} homozygotes

respiratory system

short nasal bone ( J:117491 )

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