Phenotypes associated with this allele

• Allele Symbol: Gata4^tm1Wtp
• Allele Name: targeted mutation 1, William T Pu
• Allele ID: MGI:3526853
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gata4^tm1Wtp/Gata4^tm1Wtp	involves: 129 * C57BL/6	MGI:3527223

Genotype
MGI:3527223

hm1

• Allelic Composition: Gata4^tm1Wtp/Gata4^tm1Wtp
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:94637 )

• embryos die around E13.5-E16.5

cardiovascular system

myocardial trabeculae hypoplasia ( J:94637 )

• hypoplasia of the trabecular myocardium

abnormal myocardium compact layer morphology ( J:94637 )

• the compact myocardium is hypoplastic however unlike Gata4^tm1Sho homozygotes coronary vessels are normal

• an area of dysplastic myocardium expressing compact myocardial genes but with trabecular myocardial morphology is seen

abnormal heart development ( J:94637 )

double outlet right ventricle ( J:94637 )

• a subaortic cone is present and the aortic valve is inferior, posterior, and to the right of the pulmonary valve

dilated heart right atrium ( J:94637 )

• at E13.5 the right atrium is dilated

complete atrioventricular septal defect ( J:94637 )

• a common atrioventricular canal is present at E13.5

abnormal interventricular septum morphology ( J:94637 )

• the interventricular septum has a spongiform appearance

decreased fetal cardiomyocyte proliferation ( J:94637 )

• cardiomyocyte proliferation is significantly reduced in the compact myocardium at E12.5

• however, cardiomyocyte proliferation in the trabecular myocardium is normal at at E12.5

atrioventricular valve regurgitation ( J:94637 )

• hypoplastic atrioventricular valves result in atriventricular regurgitation

homeostasis/metabolism

hydrops fetalis ( J:94637 )

• at E13.5 embryos appear edematous

muscle

myocardial trabeculae hypoplasia ( J:94637 )

• hypoplasia of the trabecular myocardium

abnormal myocardium compact layer morphology ( J:94637 )

• the compact myocardium is hypoplastic however unlike Gata4^tm1Sho homozygotes coronary vessels are normal

• an area of dysplastic myocardium expressing compact myocardial genes but with trabecular myocardial morphology is seen

decreased fetal cardiomyocyte proliferation ( J:94637 )

• cardiomyocyte proliferation is significantly reduced in the compact myocardium at E12.5

• however, cardiomyocyte proliferation in the trabecular myocardium is normal at at E12.5

cellular

decreased fetal cardiomyocyte proliferation ( J:94637 )

• cardiomyocyte proliferation is significantly reduced in the compact myocardium at E12.5

• however, cardiomyocyte proliferation in the trabecular myocardium is normal at at E12.5