All Phenotypes Gata4<tm1.1Wtp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gata4^tm1.1Wtp
targeted mutation 1.1, William T Pu
MGI:3526854

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gata4^tm1Grg/Gata4^tm1.1Wtp Tg(Nkx2-5-cre)9Eno/0	involves: 129 * C57BL/6	MGI:5427940
cn2	Gata4^tm1Grg/Gata4^tm1.1Wtp Tg(Myh6-cre)2182Mds/0	involves: 129 * C57BL/6 * FVB/N	MGI:5427939
cn3	Gata4^tm1Grg/Gata4^tm1.1Wtp Tg(Tek-cre)1Ywa/0	involves: 129 * C57BL/6 * SJL	MGI:5427937
cn4	Gata4^tm1Sho/Gata4^tm1.1Wtp Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺	involves: 129S6/SvEvTac * 129S7/SvEvBrd	MGI:3851408
cn5	Gata4^tm1Sho/Gata4^tm1.1Wtp Tg(Myh6-cre)2182Mds/0	involves: 129S6/SvEvTac * 129S7/SvEvBrd	MGI:3851409
cn6	Gata4^tm1.1Wtp/Gata4^tm1.1Wtp Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺	involves: 129S7/SvEvBrd	MGI:3639276
cn7	Gata4^tm1.1Wtp/Gata4^tm1.1Wtp Tg(Myh6-cre)2182Mds/0	involves: FVB/N	MGI:3639277

Allelic Composition	Gata4^tm1Grg/Gata4^tm1.1Wtp Tg(Nkx2-5-cre)9Eno/0
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4^tm1.1Wtp mutation (0 available); any Gata4 mutation (36 available)
Gata4^tm1Grg mutation (1 available); any Gata4 mutation (36 available)
Tg(Nkx2-5-cre)9Eno mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Growth retardation and myocardial thinning in Gata4^tm1.1Wtp/Gata4^tm1Grg Tg(Nkx2-5-cre)9Eno/0 mice

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:185124 )

• at E10.5

growth/size/body

embryonic growth retardation ( J:185124 )

• severe

cardiovascular system

thin myocardium ( J:185124 )

embryo

embryonic growth retardation ( J:185124 )

• severe

muscle

thin myocardium ( J:185124 )

Allelic Composition	Gata4^tm1Grg/Gata4^tm1.1Wtp Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129 * C57BL/6 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Hearts of Gata4^tm1.1Wtp/Gata4^tm1Grg Tg(Myh6-cre)2182Mds/0 mice appear normal

normal phenotype

no abnormal phenotype detected ( J:185124 )

• viable with no signs of embryonic growth retardation or myocardial thinning

Allelic Composition	Gata4^tm1Grg/Gata4^tm1.1Wtp Tg(Tek-cre)1Ywa/0
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Hypocellular endocardial cushions in Gata4^tm1.1Wtp/Gata4^tm1Grg Tg(Tek-cre)1Ywa/0 mice

cardiovascular system

abnormal atrioventricular cushion morphology ( J:185124 )

• hypocellular endocardial cushions are noted at E10.5

• however, no myocardial thinning is seen

growth/size/body

growth/size/body region phenotype ( J:185124 )

N	• viable with no signs of embryonic growth retardation

Allelic Composition	Gata4^tm1Sho/Gata4^tm1.1Wtp Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4^tm1.1Wtp mutation (0 available); any Gata4 mutation (36 available)
Gata4^tm1Sho mutation (0 available); any Gata4 mutation (36 available)
Nkx2-5^tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Edema, peripheral hemorrhage, and reduced coronary plexus in Gata4^tm1.1Wtp/Gata4^tm1Sho Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺ embryos and enlarged dilated ventricles and increased fibrosis in Gata4^tm1.1Wtp/Gata4^tm1Sho Tg(Myh6-cre)2182Mds/0 hearts

cardiovascular system

thin myocardium compact layer ( J:150452 )

• compact myocardium is thin

abnormal atrioventricular cushion morphology ( J:150452 )

• atrio-ventricular cushion defect is observed

abnormal coronary vessel morphology ( J:150452 )

• coronary vascular development is impaired

ventricular septal defect ( J:150452 )

• ventricular septal defect is observed

hemorrhage ( J:150452 )

• peripheral hemorrhage is observed at E13.5

homeostasis/metabolism

skin edema ( J:150452 )

• observed at E13.5

integument

skin edema ( J:150452 )

• observed at E13.5

muscle

thin myocardium compact layer ( J:150452 )

• compact myocardium is thin

Allelic Composition	Gata4^tm1Sho/Gata4^tm1.1Wtp Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129S6/SvEvTac * 129S7/SvEvBrd

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Reduced coronary microvasculature, decreased capillary density and increased fibrosis in Gata4^tm1.1Wtp/Gata4^tm1Sho Tg(Myh6-cre)2182Mds/0 hearts

cardiovascular system

dilated heart ventricle ( J:150452 )

• ventricular dilation is observed

abnormal cardiovascular system physiology ( J:150452 )

• severely diminished systolic function at 8-14 weeks

Allelic Composition	Gata4^tm1.1Wtp/Gata4^tm1.1Wtp Nkx2-5^tm1(cre)Rjs/Nkx2-5⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4^tm1.1Wtp mutation (0 available); any Gata4 mutation (36 available)
Nkx2-5^tm1(cre)Rjs mutation (1 available); any Nkx2-5 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:99203 )

• lethality by E11.5

cardiovascular system

abnormal cardiac epithelial to mesenchymal transition ( J:99203 )

• defect in the EMT of endocardial cells that normally generates cushion mesenchyme

conotruncal ridge hypoplasia ( J:99203 )

• the outflow tract endocardial cushions are small and contain few mesenchymal cells

atrioventricular cushion hypoplasia ( J:99203 )

• the atrioventricular endocardial cushions are small and contain few mesenchymal cells

common ventricle ( J:99203 )

• 15 of 21 embryos at E9.5 display a single predominant ventricular chamber that connects to an outflow tract located toward the rostral side of the chamber; the predominant ventricular chamber is the left ventricle

heart hypoplasia ( J:99203 )

• all embryos display marked myocardial hypoplasia, affecting both the compact and trabecular myocardium

heart right ventricle hypoplasia ( J:99203 )

• 6 of 21 embryos at E9.5 have a normal to mildy hypoplastic right ventricle, rest have severe right ventricle hypoplasia

pericardial effusion ( J:99203 )

• by E10.5, have large pericardial effusions

abnormal fetal cardiomyocyte proliferation ( J:99203 )

• cardiomyocyte proliferation is more severely reduced in the right ventricle than in the left ventricle

embryo

embryonic growth retardation ( J:99203 )

• by E10.5, embryos are mildly delayed in overall development

muscle

abnormal fetal cardiomyocyte proliferation ( J:99203 )

• cardiomyocyte proliferation is more severely reduced in the right ventricle than in the left ventricle

growth/size/body

embryonic growth retardation ( J:99203 )

• by E10.5, embryos are mildly delayed in overall development

homeostasis/metabolism

pericardial effusion ( J:99203 )

• by E10.5, have large pericardial effusions

cellular

abnormal fetal cardiomyocyte proliferation ( J:99203 )

• cardiomyocyte proliferation is more severely reduced in the right ventricle than in the left ventricle

Allelic Composition	Gata4^tm1.1Wtp/Gata4^tm1.1Wtp Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata4^tm1.1Wtp mutation (0 available); any Gata4 mutation (36 available)
Tg(Myh6-cre)2182Mds mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:99203 )

• lethality by E14.5

cardiovascular system

double outlet right ventricle ( J:99203 )

heart hypoplasia ( J:99203 )

• marked myocardial hyperplasia

abnormal fetal cardiomyocyte proliferation ( J:99203 )

• reduction in cardiomyocyte proliferation

muscle

abnormal fetal cardiomyocyte proliferation ( J:99203 )

• reduction in cardiomyocyte proliferation

cellular

abnormal fetal cardiomyocyte proliferation ( J:99203 )

• reduction in cardiomyocyte proliferation

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