All Phenotypes Plekha1<Gt(ROSA)82Sor> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Plekha1^{Gt(ROSA)82Sor}
gene trapped 82, Philippe Soriano
MGI:3526857

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plekha1^{Gt(ROSA)82Sor}/Plekha1^{Gt(ROSA)82Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3822916
hm2	Plekha1^{Gt(ROSA)82Sor}/Plekha1^{Gt(ROSA)82Sor}	involves: 129S4/SvJaeSor	MGI:3717116
cx3	Pdgfrb^tm1Sor/Pdgfrb⁺ Plekha1^{Gt(ROSA)82Sor}/Plekha1^{Gt(ROSA)82Sor}	either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)	MGI:3822996
cx4	Pdgfra^tm1Sor/Pdgfra⁺ Plekha1^{Gt(ROSA)82Sor}/Plekha1^{Gt(ROSA)82Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3822917
cx5	Plekha1^{Gt(ROSA)82Sor}/Plekha1^{Gt(ROSA)82Sor} Tiparp^{Gt(ROSA)79Sor}/Tiparp⁺	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3823034
cx6	Pdgfra^tm2Sor/Pdgfra⁺ Plekha1^{Gt(ROSA)82Sor}/Plekha1^{Gt(ROSA)82Sor}	involves: 129S4/SvJaeSor	MGI:3717138

Allelic Composition	Plekha1^{Gt(ROSA)82Sor}/Plekha1^{Gt(ROSA)82Sor}
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plekha1^{Gt(ROSA)82Sor} mutation (1 available); any Plekha1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal testis morphology ( J:142042 )

• testis morphology appears normal at P7, but by P20 mutants show a reduction in the testis interstitium

• reduction in the numbers of vascular smooth muscle cells in the testis

abnormal testis cord formation ( J:142042 )

• by p20, mutants exhibit gaps in the spermatocyte layers of the testis cords

decreased Leydig cell number ( J:142042 )

• reduction in Leydig cells before and during early adolescence

small testis ( J:142042 )

• reduction in testis size is observed by P42

abnormal spermatogenesis ( J:142042 )

• complete loss of spermatogenesis by 10 weeks of age

abnormal spermatocyte morphology ( J:142042 )

• loss of spermatocytes from the testis cords by P42

male infertility ( J:142042 )

homeostasis/metabolism

decreased circulating testosterone level ( J:142042 )

endocrine/exocrine glands

abnormal testis morphology ( J:142042 )

• testis morphology appears normal at P7, but by P20 mutants show a reduction in the testis interstitium

• reduction in the numbers of vascular smooth muscle cells in the testis

abnormal testis cord formation ( J:142042 )

• by p20, mutants exhibit gaps in the spermatocyte layers of the testis cords

decreased Leydig cell number ( J:142042 )

• reduction in Leydig cells before and during early adolescence

small testis ( J:142042 )

• reduction in testis size is observed by P42

cardiovascular system

abnormal vascular smooth muscle morphology ( J:142042 )

• reduction in numbers of vascular smooth muscle cells in the testis

muscle

abnormal vascular smooth muscle morphology ( J:142042 )

• reduction in numbers of vascular smooth muscle cells in the testis

cellular

abnormal spermatocyte morphology ( J:142042 )

• loss of spermatocytes from the testis cords by P42

Allelic Composition	Plekha1^{Gt(ROSA)82Sor}/Plekha1^{Gt(ROSA)82Sor}
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plekha1^{Gt(ROSA)82Sor} mutation (1 available); any Plekha1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:117491 )

• 25% of mice die by week 2

growth/size/body

increased body weight ( J:117491 )

• in males following adolescence

Allelic Composition	Pdgfrb^tm1Sor/Pdgfrb⁺ Plekha1^{Gt(ROSA)82Sor}/Plekha1^{Gt(ROSA)82Sor}
Genetic Background	either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrb^tm1Sor mutation (1 available); any Pdgfrb mutation (84 available)
Plekha1^{Gt(ROSA)82Sor} mutation (1 available); any Plekha1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

male infertility ( J:142042 )

Allelic Composition	Pdgfra^tm1Sor/Pdgfra⁺ Plekha1^{Gt(ROSA)82Sor}/Plekha1^{Gt(ROSA)82Sor}
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfra^tm1Sor mutation (0 available); any Pdgfra mutation (86 available)
Plekha1^{Gt(ROSA)82Sor} mutation (1 available); any Plekha1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal ovary morphology ( J:142042 )

• ovaries of females older than 8 weeks exhibit a hyperplastic stroma, containing multiple atretic follicles

• reduction in numbers of vascular smooth muscle cells in the ovaries

absent corpus luteum ( J:142042 )

decreased tertiary ovarian follicle number ( J:142042 )

• decrease in numbers of later stage antral follicles

decreased theca cell number ( J:142042 )

• reduction in theca cells

small ovary ( J:142042 )

uterus hypoplasia ( J:142042 )

• uterus is hypoplastic, with major uterine layers present but underdeveloped

anovulation ( J:142042 )

• little or no ovulation

female infertility ( J:142042 )

• 71% of females are sterile

male infertility ( J:142042 )

homeostasis/metabolism

decreased circulating estradiol level ( J:142042 )

endocrine/exocrine glands

abnormal ovary morphology ( J:142042 )

• ovaries of females older than 8 weeks exhibit a hyperplastic stroma, containing multiple atretic follicles

• reduction in numbers of vascular smooth muscle cells in the ovaries

absent corpus luteum ( J:142042 )

decreased tertiary ovarian follicle number ( J:142042 )

• decrease in numbers of later stage antral follicles

decreased theca cell number ( J:142042 )

• reduction in theca cells

small ovary ( J:142042 )

cardiovascular system

abnormal vascular smooth muscle morphology ( J:142042 )

• reduction in numbers of vascular smooth muscle cells in the ovaries

muscle

abnormal vascular smooth muscle morphology ( J:142042 )

• reduction in numbers of vascular smooth muscle cells in the ovaries

Allelic Composition	Plekha1^{Gt(ROSA)82Sor}/Plekha1^{Gt(ROSA)82Sor} Tiparp^{Gt(ROSA)79Sor}/Tiparp⁺
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plekha1^{Gt(ROSA)82Sor} mutation (1 available); any Plekha1 mutation (54 available)
Tiparp^{Gt(ROSA)79Sor} mutation (1 available); any Tiparp mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:142042 )

N	• double mutants are fertile unlike single homozygous Plekha1 mutant mice

Allelic Composition	Pdgfra^tm2Sor/Pdgfra⁺ Plekha1^{Gt(ROSA)82Sor}/Plekha1^{Gt(ROSA)82Sor}
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfra^tm2Sor mutation (0 available); any Pdgfra mutation (86 available)
Plekha1^{Gt(ROSA)82Sor} mutation (1 available); any Plekha1 mutation (54 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with Plekha1^{Gt(ROSA)82Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

cleft palate ( J:117491 )

• reduced or completely cleft palates are present in all mice

complete cleft palate ( J:117491 )

broad snout ( J:117491 )

• shorter and wider than in Plekha1^{Gt(ROSA)82Sor} homozygotes

short snout ( J:117491 )

• shorter and wider than in Plekha1^{Gt(ROSA)82Sor} homozygotes

midline facial cleft ( J:117491 )

• 2 of 7 mice have clefts that extend through the cartilaginous nasal capsule, palate and frontal bones

digestive/alimentary system

cleft palate ( J:117491 )

• reduced or completely cleft palates are present in all mice

complete cleft palate ( J:117491 )

skeleton

abnormal skeleton morphology ( J:117491 )

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with Plekha1^{Gt(ROSA)82Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

growth/size/body

short nasal bone ( J:117491 )

cleft palate ( J:117491 )

• reduced or completely cleft palates are present in all mice

complete cleft palate ( J:117491 )

broad snout ( J:117491 )

• shorter and wider than in Plekha1^{Gt(ROSA)82Sor} homozygotes

short snout ( J:117491 )

• shorter and wider than in Plekha1^{Gt(ROSA)82Sor} homozygotes

midline facial cleft ( J:117491 )

• 2 of 7 mice have clefts that extend through the cartilaginous nasal capsule, palate and frontal bones

respiratory system

short nasal bone ( J:117491 )

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