All Phenotypes Zfp950<Gt(ROSA)76Sor> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfp950^{Gt(ROSA)76Sor}/Zfp950^{Gt(ROSA)76Sor}	involves: 129S4/SvJaeSor	MGI:3717091
cx2	Zfp950^{Gt(ROSA)76Sor}/Zfp950^{Gt(ROSA)76Sor} Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor}	involves: 129S4/SvJaeSor	MGI:3717128
cx3	Zfp950^{Gt(ROSA)76Sor}/Zfp950⁺ Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor}	involves: 129S4/SvJaeSor	MGI:3717130
cx4	Zfp950^{Gt(ROSA)76Sor}/Zfp950^{Gt(ROSA)76Sor} Pdgfra^tm2Sor/Pdgfra⁺	involves: 129S4/SvJaeSor	MGI:3717136

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:117491 )

• 8% of mice die by week 1

skeleton

abnormal skeleton morphology ( J:117491 )

• abnormal neural crest derived and thoracic skeleton

small presphenoid bone ( J:117491 )

• 73% of homozygous mice have smaller presphenoid bone processes that are less extended towards the midline

decreased palatine bone horizontal plate size ( J:117491 )

• 73% of homozygous mice have smaller palatine bone processes that are less extended towards the midline

abnormal sternum morphology ( J:117491 )

• 27% of mice have sternum defects including asymmetric or additional fusion of ribs and gaps in the sternum

asymmetric sternocostal joints ( J:117491 )

increased rib number ( J:117491 )

• 47% of mice have a 14th pair of ribs

abnormal vertebrae morphology ( J:117491 )

• 33% of mice have widened vertebral arches and forked vertebrae

abnormal vertebral arch morphology ( J:117491 )

• 33% of mice have widened vertebral arches and forked vertebrae

renal/urinary system

abnormal kidney morphology ( J:117491 )

abnormal renal glomerulus morphology ( J:117491 )

• glomeruli are often degraded

• smooth muscle cell number is reduced in the glomeruli

• migration of smooth muscle cells in glomeruli is impaired

small kidney ( J:117491 )

pale kidney ( J:117491 )

abnormal kidney physiology ( J:117491 )

• decrease in kidney function

kidney inflammation ( J:117491 )

• kidney is swollen in sections and blood filled

hematopoietic system

anemia ( J:117491 )

• by week 6

decreased erythrocyte cell number ( J:117491 )

• by week 6

decreased hematocrit ( J:117491 )

• by week 6

decreased hemoglobin content ( J:117491 )

• by week 6

polychromatophilia ( J:117491 )

reticulocytosis ( J:117491 )

• an increase in immature red blood cells is observed compared to wild-type mice

homeostasis/metabolism

increased blood urea nitrogen level ( J:117491 )

muscle

abnormal smooth muscle morphology ( J:117491 )

• smooth muscle cell number is reduced in the glomeruli

cardiovascular system

abnormal blood vessel morphology ( J:117491 )

hemorrhage ( J:117491 )

• at E11.5-E18.5

immune system

kidney inflammation ( J:117491 )

• kidney is swollen in sections and blood filled

cellular

abnormal cell migration ( J:117491 )

• migration of smooth muscle cells in glomeruli is impaired

craniofacial

small presphenoid bone ( J:117491 )

• 73% of homozygous mice have smaller presphenoid bone processes that are less extended towards the midline

abnormal palate morphology ( J:117491 )

• irregularities in fusion persist into adulthood

decreased palatine bone horizontal plate size ( J:117491 )

• 73% of homozygous mice have smaller palatine bone processes that are less extended towards the midline

digestive/alimentary system

abnormal palate morphology ( J:117491 )

• irregularities in fusion persist into adulthood

decreased palatine bone horizontal plate size ( J:117491 )

• 73% of homozygous mice have smaller palatine bone processes that are less extended towards the midline

growth/size/body

abnormal palate morphology ( J:117491 )

• irregularities in fusion persist into adulthood

decreased palatine bone horizontal plate size ( J:117491 )

• 73% of homozygous mice have smaller palatine bone processes that are less extended towards the midline

Allelic Composition	Zfp950^{Gt(ROSA)76Sor}/Zfp950^{Gt(ROSA)76Sor} Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor}
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arid5b^{Gt(ROSA)75Sor} mutation (1 available); any Arid5b mutation (136 available)
Zfp950^{Gt(ROSA)76Sor} mutation (1 available); any Zfp950 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:117491 )

• mice die within hours of birth

skeleton

abnormal skeleton morphology ( J:117491 )

• skeletal defects are more severe than in single transgenic

absent palatine bone horizontal plate ( J:117491 )

• near-absence of the palatin process in 4 of 5 mice

craniofacial

absent palatine bone horizontal plate ( J:117491 )

• near-absence of the palatin process in 4 of 5 mice

cleft palate ( J:117491 )

• partial or full cleft

digestive/alimentary system

absent palatine bone horizontal plate ( J:117491 )

• near-absence of the palatin process in 4 of 5 mice

cleft palate ( J:117491 )

• partial or full cleft

growth/size/body

absent palatine bone horizontal plate ( J:117491 )

• near-absence of the palatin process in 4 of 5 mice

cleft palate ( J:117491 )

• partial or full cleft

Allelic Composition	Zfp950^{Gt(ROSA)76Sor}/Zfp950⁺ Arid5b^{Gt(ROSA)75Sor}/Arid5b^{Gt(ROSA)75Sor}
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

broad snout ( J:117491 )

• wider snouts than in either single homozygous transgenic mouse

growth/size/body

short nasal bone ( J:117491 )

broad snout ( J:117491 )

• wider snouts than in either single homozygous transgenic mouse

decreased body height ( J:117491 )

• shorter than in either single homozygous transgenic mouse

skeleton

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

respiratory system

short nasal bone ( J:117491 )

Allelic Composition	Zfp950^{Gt(ROSA)76Sor}/Zfp950^{Gt(ROSA)76Sor} Pdgfra^tm2Sor/Pdgfra⁺
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfra^tm2Sor mutation (0 available); any Pdgfra mutation (87 available)
Zfp950^{Gt(ROSA)76Sor} mutation (1 available); any Zfp950 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal skeleton morphology ( J:117491 )

• skeletal defects are more severe than in 5830428H23Rik^{Gt(ROSA)76Sor} homozygotes

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with 5830428H23Rik^{Gt(ROSA)76Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

craniofacial

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with 5830428H23Rik^{Gt(ROSA)76Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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