All Phenotypes 2610005L07Rik<Gt(ROSA)73Sor> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

2610005L07Rik^{Gt(ROSA)73Sor}
gene trapped 73, Philippe Soriano
MGI:3526861

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	2610005L07Rik^{Gt(ROSA)73Sor}/2610005L07Rik^{Gt(ROSA)73Sor}	involves: 129S4/SvJaeSor	MGI:3717112
cx2	2610005L07Rik^{Gt(ROSA)73Sor}/2610005L07Rik^{Gt(ROSA)73Sor} Pdgfra^tm1Sor/Pdgfra⁺	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3823024
cx3	2610005L07Rik^{Gt(ROSA)73Sor}/2610005L07Rik^{Gt(ROSA)73Sor} Pdgfra^tm2Sor/Pdgfra⁺	involves: 129S4/SvJaeSor	MGI:3717137

Allelic Composition	2610005L07Rik^{Gt(ROSA)73Sor}/2610005L07Rik^{Gt(ROSA)73Sor}
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
2610005L07Rik^{Gt(ROSA)73Sor} mutation (1 available); any 2610005L07Rik mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:117491 )

• fewer mice (9%) are born than expected (25%)

skeleton

abnormal skeleton morphology ( J:117491 )

• abnormal neural crest derived and thoracic skeleton

abnormal neurocranium morphology ( J:117491 )

• 100% of mice have reduced calvarial bones at the midline with increases in the gaps between frontal bones

abnormal frontal bone morphology ( J:117491 )

• increases in the gaps between frontal bones

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

abnormal sternum morphology ( J:117491 )

• 40% of mice have sternum defects including asymmetric or additional fusion of ribs and gaps in the sternum

asymmetric sternocostal joints ( J:117491 )

cellular

increased fibroblast cell migration ( J:117491 )

• mouse embryonic fibroblast cells show increased migration in a scratch test in response to PDGF stimulation

craniofacial

abnormal neurocranium morphology ( J:117491 )

• 100% of mice have reduced calvarial bones at the midline with increases in the gaps between frontal bones

abnormal frontal bone morphology ( J:117491 )

• increases in the gaps between frontal bones

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

broad snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

short snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

growth/size/body

short nasal bone ( J:117491 )

broad snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

short snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

respiratory system

short nasal bone ( J:117491 )

Allelic Composition	2610005L07Rik^{Gt(ROSA)73Sor}/2610005L07Rik^{Gt(ROSA)73Sor} Pdgfra^tm1Sor/Pdgfra⁺
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
2610005L07Rik^{Gt(ROSA)73Sor} mutation (1 available); any 2610005L07Rik mutation (13 available)
Pdgfra^tm1Sor mutation (0 available); any Pdgfra mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal ovary morphology ( J:142042 )

• ovaries of females older than 8 weeks exhibit a hyperplastic stroma, containing multiple atretic follicles

• reduction in numbers of vascular smooth muscle cells in the ovaries

decreased corpora lutea number ( J:142042 )

• number and incidence of corpora lutea are reduced

decreased tertiary ovarian follicle number ( J:142042 )

• decrease in numbers of later stage antral follicles

decreased theca cell number ( J:142042 )

• reduction in theca cells

small ovary ( J:142042 )

uterus hypoplasia ( J:142042 )

• uterus is hypoplastic, with major uterine layers present but underdeveloped

anovulation ( J:142042 )

• little or no ovulation

female infertility ( J:142042 )

• 35% of females are sterile

homeostasis/metabolism

decreased circulating estradiol level ( J:142042 )

endocrine/exocrine glands

abnormal ovary morphology ( J:142042 )

• ovaries of females older than 8 weeks exhibit a hyperplastic stroma, containing multiple atretic follicles

• reduction in numbers of vascular smooth muscle cells in the ovaries

decreased corpora lutea number ( J:142042 )

• number and incidence of corpora lutea are reduced

decreased tertiary ovarian follicle number ( J:142042 )

• decrease in numbers of later stage antral follicles

decreased theca cell number ( J:142042 )

• reduction in theca cells

small ovary ( J:142042 )

cardiovascular system

abnormal vascular smooth muscle morphology ( J:142042 )

• reduction in numbers of vascular smooth muscle cells in the ovaries

muscle

abnormal vascular smooth muscle morphology ( J:142042 )

• reduction in numbers of vascular smooth muscle cells in the ovaries

Allelic Composition	2610005L07Rik^{Gt(ROSA)73Sor}/2610005L07Rik^{Gt(ROSA)73Sor} Pdgfra^tm2Sor/Pdgfra⁺
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
2610005L07Rik^{Gt(ROSA)73Sor} mutation (1 available); any 2610005L07Rik mutation (13 available)
Pdgfra^tm2Sor mutation (0 available); any Pdgfra mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal skeleton morphology ( J:117491 )

• skeletal defects are more severe than in 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

craniofacial

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

broad snout ( J:117491 )

• snout is shorter and wider than in 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes

short snout ( J:117491 )

• snout is shorter and wider than in 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes

growth/size/body

short nasal bone ( J:117491 )

broad snout ( J:117491 )

• snout is shorter and wider than in 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes

short snout ( J:117491 )

• snout is shorter and wider than in 2610005L07Rik^{Gt(ROSA)73Sor} homozygotes

respiratory system

short nasal bone ( J:117491 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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