All Phenotypes Tiparp<Gt(ROSA)79Sor> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3822998
hm2	Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor}	involves: 129S4/SvJaeSor	MGI:3717120
hm3	Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor}	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6J	MGI:6449734
cx4	Pdgfrb^tm1Sor/Pdgfrb⁺ Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor}	either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)	MGI:3823002
cx5	Pdgfra^tm1Sor/Pdgfra⁺ Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor}	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3823001
cx6	Plekha1^{Gt(ROSA)82Sor}/Plekha1^{Gt(ROSA)82Sor} Tiparp^{Gt(ROSA)79Sor}/Tiparp⁺	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)	MGI:3823034
cx7	Pdgfra^tm2Sor/Pdgfra⁺ Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor}	involves: 129S4/SvJaeSor	MGI:3717135

Allelic Composition	Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor}
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tiparp^{Gt(ROSA)79Sor} mutation (1 available); any Tiparp mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

increased corpora lutea number ( J:142042 )

• females exhibit an abnormally large number of corpora lutea

increased tertiary ovarian follicle number ( J:142042 )

• females exhibit an abnormally large number of late stage antral follicles

enlarged ovary ( J:142042 )

ovary cyst ( J:142042 )

• occasionally develop hemorrhagic cysts

enlarged uterus ( J:142042 )

long gestation period ( J:142042 )

• the few observed pregnancies last longer, between 21 and 23 days instead of 19 days, however pups are either born dead or mothers show declining health and were sacrificed

prolonged estrous cycle ( J:142042 )

• length of estrus cycle is protracted, lasting up to 4 days instead of the normal 13 hours

reduced female fertility ( J:142042 )

decreased litter size ( J:142042 )

• smaller litter size (2.8 vs 9.3 in wild type)

homeostasis/metabolism

decreased circulating estradiol level ( J:142042 )

endocrine/exocrine glands

increased corpora lutea number ( J:142042 )

• females exhibit an abnormally large number of corpora lutea

increased tertiary ovarian follicle number ( J:142042 )

• females exhibit an abnormally large number of late stage antral follicles

enlarged ovary ( J:142042 )

ovary cyst ( J:142042 )

• occasionally develop hemorrhagic cysts

growth/size/body

enlarged ovary ( J:142042 )

ovary cyst ( J:142042 )

• occasionally develop hemorrhagic cysts

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:117491 )

• 32% of mice die by week 2

skeleton

abnormal skeleton morphology ( J:117491 )

• abnormal neural crest derived and thoracic skeleton

abnormal neurocranium morphology ( J:117491 )

• 55% of mice have reduced calvarial bones at the midline with increases in the gaps between frontal bones

abnormal frontal bone morphology ( J:117491 )

• increases in the gaps between frontal bones

small presphenoid bone ( J:117491 )

• 78% of homozygous mice have smaller presphenoid bone processes that are less extended towards the midline

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

decreased palatine bone horizontal plate size ( J:117491 )

• 78% of homozygous mice have smaller palatine bone processes that are less extended towards the midline

abnormal sternum morphology ( J:117491 )

• 44% of mice have sternum defects including asymmetric or additional fusion of ribs and gaps in the sternum

asymmetric sternocostal joints ( J:117491 )

renal/urinary system

kidney inflammation ( J:117491 )

• kidney is swollen in sections and blood filled

abnormal kidney morphology ( J:117491 )

abnormal renal glomerulus morphology ( J:117491 )

• glomeruli are often degraded

• excess smooth muscle cells are found in the glomeruli

small kidney ( J:117491 )

pale kidney ( J:117491 )

hematopoietic system

anemia ( J:117491 )

• by week 6

decreased erythrocyte cell number ( J:117491 )

• by week 6

decreased hematocrit ( J:117491 )

• by week 6

decreased hemoglobin content ( J:117491 )

• by week 6

polychromatophilia ( J:117491 )

reticulocytosis ( J:117491 )

• an increase in immature red blood cells is observed compared to wild-type mice

homeostasis/metabolism

increased blood urea nitrogen level ( J:117491 )

cardiovascular system

abnormal blood vessel morphology ( J:117491 )

hemorrhage ( J:117491 )

• at E11.5-E18.5

muscle

abnormal smooth muscle morphology ( J:117491 )

• excess smooth muscle cells are found in the glomeruli

immune system

kidney inflammation ( J:117491 )

• kidney is swollen in sections and blood filled

craniofacial

abnormal neurocranium morphology ( J:117491 )

• 55% of mice have reduced calvarial bones at the midline with increases in the gaps between frontal bones

abnormal frontal bone morphology ( J:117491 )

• increases in the gaps between frontal bones

small presphenoid bone ( J:117491 )

• 78% of homozygous mice have smaller presphenoid bone processes that are less extended towards the midline

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

abnormal palate morphology ( J:117491 )

• irregularities in fusion persist into adulthood

decreased palatine bone horizontal plate size ( J:117491 )

• 78% of homozygous mice have smaller palatine bone processes that are less extended towards the midline

broad snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

short snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

digestive/alimentary system

abnormal palate morphology ( J:117491 )

• irregularities in fusion persist into adulthood

decreased palatine bone horizontal plate size ( J:117491 )

• 78% of homozygous mice have smaller palatine bone processes that are less extended towards the midline

growth/size/body

short nasal bone ( J:117491 )

abnormal palate morphology ( J:117491 )

• irregularities in fusion persist into adulthood

decreased palatine bone horizontal plate size ( J:117491 )

• 78% of homozygous mice have smaller palatine bone processes that are less extended towards the midline

broad snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

short snout ( J:117491 )

• snout is shorter and wider than in wild-type mice

respiratory system

short nasal bone ( J:117491 )

Allelic Composition	Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor}
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tiparp^{Gt(ROSA)79Sor} mutation (1 available); any Tiparp mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased fasting circulating glucose level ( J:250417 )

• dioxin-treated mice show reduced fasting serum glucose levels from day 1 to 3

increased circulating alanine transaminase level ( J:250417 )

• dioxin-treated mice show increased serum alanine aminotransferase activity

increased susceptibility to xenobiotic induced morbidity/mortality ( J:250417 )

• mice exhibit increased sensitivity to dioxin-induced lethality, with mice becoming moribund between 3 and 5 days

increased physiological sensitivity to xenobiotic ( J:250417 )

• mice exhibit increased sensitivity to dioxin-induced toxicity, showing decreased body weight, reduced fasting serum glucose levels, induction of thymic involution, hepatomegaly, liver degeneration, and increased hepatosteatosis

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:250417 )

• mice exhibit increased sensitivity to dioxin-induced lethality, with mice becoming moribund between 3 and 5 days

endocrine/exocrine glands

abnormal thymus involution ( J:250417 )

• dioxin-treatment induces thymic involution

growth/size/body

increased susceptibility to weight loss ( J:250417 )

• dioxin-treated mice show reduced body weight on day 3 due to decreased food intake on days 1 and 2

enlarged liver ( J:250417 )

• dioxin-treated mice show hepatomegaly

hematopoietic system

abnormal thymus involution ( J:250417 )

• dioxin-treatment induces thymic involution

immune system

abnormal thymus involution ( J:250417 )

• dioxin-treatment induces thymic involution

liver/biliary system

enlarged liver ( J:250417 )

• dioxin-treated mice show hepatomegaly

hepatic steatosis ( J:250417 )

• mice exhibit increased dioxin-induced hepatosteatosis, showing increases in intrahepatic triglycerides, cholesterol and free fatty acids levels

• expression analysis suggest that increased sensitivity to dioxin-induced hepatosteatosis is due to increased uptake of circulating lipids rather than increased hepatic lipogenesis

liver degeneration ( J:250417 )

• dioxin-treated mice show increased degenerative changes in the liver, including focal inflammatory infiltration and increased cytoplasmic clearing of periportal hepatocytes on day 1 and microvesicular steatosis with regions of focal vacuolation on day 3

• dioxin-treated mice exhibit increased hepatic expression of Il1-beta and Cxcl2

Allelic Composition	Pdgfrb^tm1Sor/Pdgfrb⁺ Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor}
Genetic Background	either: (involves: 129S4/SvJaeSor * 129S7/SvEvBrd) or (involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfrb^tm1Sor mutation (1 available); any Pdgfrb mutation (87 available)
Tiparp^{Gt(ROSA)79Sor} mutation (1 available); any Tiparp mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

female infertility ( J:142042 )

Allelic Composition	Pdgfra^tm1Sor/Pdgfra⁺ Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor}
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfra^tm1Sor mutation (0 available); any Pdgfra mutation (88 available)
Tiparp^{Gt(ROSA)79Sor} mutation (1 available); any Tiparp mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

female infertility ( J:142042 )

Allelic Composition	Plekha1^{Gt(ROSA)82Sor}/Plekha1^{Gt(ROSA)82Sor} Tiparp^{Gt(ROSA)79Sor}/Tiparp⁺
Genetic Background	either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plekha1^{Gt(ROSA)82Sor} mutation (1 available); any Plekha1 mutation (54 available)
Tiparp^{Gt(ROSA)79Sor} mutation (1 available); any Tiparp mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:142042 )

N	• double mutants are fertile unlike single homozygous Plekha1 mutant mice

Allelic Composition	Pdgfra^tm2Sor/Pdgfra⁺ Tiparp^{Gt(ROSA)79Sor}/Tiparp^{Gt(ROSA)79Sor}
Genetic Background	involves: 129S4/SvJaeSor

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pdgfra^tm2Sor mutation (0 available); any Pdgfra mutation (88 available)
Tiparp^{Gt(ROSA)79Sor} mutation (1 available); any Tiparp mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with Tiparp^{Gt(ROSA)79Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

broad snout ( J:117491 )

• shorter and wider than in Tiparp^{Gt(ROSA)79Sor} homozygotes

short snout ( J:117491 )

• shorter and wider than in Tiparp^{Gt(ROSA)79Sor} homozygotes

skeleton

abnormal skeleton morphology ( J:117491 )

• skeletal defects are more severe than in Tiparp^{Gt(ROSA)79Sor} homozygotes

abnormal frontal bone morphology ( J:117491 )

• distance between the frontal bones is increased compared with Tiparp^{Gt(ROSA)79Sor} homozygotes and often accompanied by outgrowth of the interfrontal bone

short premaxilla ( J:117491 )

short maxilla ( J:117491 )

short nasal bone ( J:117491 )

growth/size/body

short nasal bone ( J:117491 )

broad snout ( J:117491 )

• shorter and wider than in Tiparp^{Gt(ROSA)79Sor} homozygotes

short snout ( J:117491 )

• shorter and wider than in Tiparp^{Gt(ROSA)79Sor} homozygotes

respiratory system

short nasal bone ( J:117491 )

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