mortality/aging
• 18% of mice die by week 2
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skeleton
• abnormal neural crest derived and thoracic skeleton
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• 38% aof homozygous mice have smaller presphenoid bone processes that are less extended towards the midline
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• 38% of homozygous mice have smaller palatine bone processes that are less extended towards the midline
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• 15% of mice have sternum defects including asymmetric or additional fusion of ribs and gaps in the sternum
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• 18% of mice die by week 2
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craniofacial
• 38% aof homozygous mice have smaller presphenoid bone processes that are less extended towards the midline
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• irregularities in fusion persist into adulthood
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• 38% of homozygous mice have smaller palatine bone processes that are less extended towards the midline
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digestive/alimentary system
• irregularities in fusion persist into adulthood
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• 38% of homozygous mice have smaller palatine bone processes that are less extended towards the midline
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growth/size/body
• irregularities in fusion persist into adulthood
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• 38% of homozygous mice have smaller palatine bone processes that are less extended towards the midline
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