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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fth1tm1Kjt
targeted mutation 1, Khristy J Thompson
MGI:3526872
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fth1tm1Kjt/Fth1tm1Kjt involves: 129S/SvEvBrd * C57BL/6 MGI:4440510
ht2
 		Fth1tm1Kjt/Fth1+ involves: 129S/SvEvBrd * C57BL/6 MGI:4440511


Genotype
MGI:4440510
hm1
Allelic
Composition		 Fth1tm1Kjt/Fth1tm1Kjt
Genetic
Background		 involves: 129S/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fth1tm1Kjt mutation (0 available); any Fth1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:4440511
ht2
Allelic
Composition		 Fth1tm1Kjt/Fth1+
Genetic
Background		 involves: 129S/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fth1tm1Kjt mutation (0 available); any Fth1 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron physiology ( J:158718 )
• neurons exhibit a decrease in superoxide dismutase activity with increased Bax and caspase-3 staining compared with wild-type cells indicating oxidative stress

cellular
oxidative stress ( J:158718 )
• neurons exhibit a decrease in superoxide dismutase activity with increased Bax and caspase-3 staining compared with wild-type cells indicating oxidative stress




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory