Analysis Tools
cardiovascular system
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• myocyte disarray and loss of the close lateral alignment of myofibrils are seen
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• heart to body weight ratios are increased as is the thickness of the anterior and posterior walls
• hypertrophy is seen in 3 week old homozygotes
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• foci of interstitial fibrosis were seen in 3 out of 5 homozygotes
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• Ca2+ sensitivity of tension is reduced in myocytes from mutant hearts
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• left ventricular fractional shortening is significantly reduced
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• skinned cardiomyocytes from homozygotes exhibit faster loaded shortening velocities, greater power output, and increased force redevelopment rates, due to increased crossbridge interaction kinetics resulting from absence of myosin head constraints
• peak normalized power output is increased by 26% in mutant cardiomyocytes during maximal Ca2+ activations
• peak power output is increased to an even greater extent (46%) during half-maximal Ca2+ activations
• the rate constant of force redevelopment (ktr) is unaltered during maximal Ca2+ activations; however, ktr at half-maximal Ca2+ activation is significantly greater in mutant cardiomyocytes relative to wild-type
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• hypertrophic cardiomyopathy is seen
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growth/size/body
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• heart to body weight ratios are increased as is the thickness of the anterior and posterior walls
• hypertrophy is seen in 3 week old homozygotes
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muscle
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• myocyte disarray and loss of the close lateral alignment of myofibrils are seen
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• Ca2+ sensitivity of tension is reduced in myocytes from mutant hearts
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• left ventricular fractional shortening is significantly reduced
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• hypertrophic cardiomyopathy is seen
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cellular
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• foci of interstitial fibrosis were seen in 3 out of 5 homozygotes
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hypertrophic cardiomyopathy 4 | DOID:0110310 |
OMIM:115197 |
J:95725 | |
