Phenotypes associated with this allele

• Allele Symbol: Tlr1^tm1Flv
• Allele Name: targeted mutation 1, Richard A Flavell
• Allele ID: MGI:3526882
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tlr1^tm1Flv/Tlr1^tm1Flv	involves: 129S1/Sv	MGI:3527273

Genotype
MGI:3527273

hm1

• Allelic Composition: Tlr1^tm1Flv/Tlr1^tm1Flv
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased immunoglobulin level ( J:95726 )

• lower antibody titers are seen in response to immunization with lipidated OspA (Lyme disease vaccine) alone however titers are similar to wild-type when immunized with OspA plus complete Freund's adjuvant

abnormal macrophage physiology ( J:95726 )

• Il-6 (but not IL-10) production after stimulation with OspA or peptoglycan is reduced compared to wild-type

increased susceptibility to bacterial infection ( J:95726 )

• the spirochete burden is significantly increased 2 weeks after infection with Borrelia burgdorferi, however antibody production, degree of arthritis and carditis, and time to disease resolution are the same as in wild-type mice

hematopoietic system

decreased immunoglobulin level ( J:95726 )

• lower antibody titers are seen in response to immunization with lipidated OspA (Lyme disease vaccine) alone however titers are similar to wild-type when immunized with OspA plus complete Freund's adjuvant

abnormal macrophage physiology ( J:95726 )

• Il-6 (but not IL-10) production after stimulation with OspA or peptoglycan is reduced compared to wild-type