All Phenotypes Umod<tm1Xrw> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Umod^tm1Xrw/Umod^tm1Xrw	129S/SvEv-Umod^tm1Xrw	MGI:4361712
hm2	Umod^tm1Xrw/Umod^tm1Xrw	B6.129S6-Umod^tm1Xrw	MGI:5429727
hm3	Umod^tm1Xrw/Umod^tm1Xrw	involves: 129S6/SvEvTac	MGI:3527894
ht4	Umod^tm1Xrw/Umod⁺	B6.129S6-Umod^tm1Xrw	MGI:5429728
cx5	Spp1^tm1Blh/Spp1^tm1Blh Umod^tm1Xrw/Umod^tm1Xrw	129S/SvEv-Spp1^tm1Blh Umod^tm1Xrw	MGI:4361714

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal urine homeostasis ( J:127526 , J:163552 )

• at 2-3 months of age, urine chloride, phosphorus, and calcium phosphate content are higher than in wild-type mice; however, mice exhibit normal urine creatinine, calcium, magnesium, and citrate levels (J:127526)

• at 5-8 months of age, the concentrations of Cl, K, Ca, Mg, P, uric acid, creatinine, and ammonium are nearly doubled relative to wild-type controls (J:163552)

• at 5-8 months of age, mice exhibit urinary supersaturation of calcium phosphate (brushite), uric acid and sodium urate, but not calcium oxalate (J:163552)

increased urine creatinine level ( J:163552 )

increased urine ammonia level ( J:163552 )

increased urine chloride ion level ( J:127526 , J:163552 )

• urine chloride ion levels are higher than in wild-type mice (J:127526)

increased urine potassium level ( J:163552 )

increased urine sodium level ( J:127526 )

abnormal urine organic anion level ( J:163552 )

• at 5-8 months of age, the concentrations of organic anions such as citrate and oxalate are slightly lower than in wild-type controls

decreased urine citrate level ( J:163552 )

• at 5-8 months of age, the concentrations of citrate are slightly lower than in wild-type controls

increased urine calcium level ( J:163552 )

increased urine magnesium level ( J:163552 )

decreased urine pH ( J:163552 )

• at 5-8 months of age, urine pH is significantly lower than that in wild-type controls

increased urine phosphate level ( J:127526 , J:163552 )

• urine phosphorus and calcium phosphate levels are higher than in wild-type mice (J:127526)

increased urine uric acid level ( J:163552 )

crystalluria ( J:127526 )

• under hyperoxaluria conditions, 71% of mice exhibit moderate amounts of calcium crystalluria and renal calcium crystal formation unlike similarly treated wild-type mice

• after 1 month of hyperoxaluria, 15% of mice develop large crystalline deposits at the tip of the renal papillae that can block the proximal portions of the collecting ducts unlike similarly treated wild-type mice

• following hyperoxaluria, mice develop stones unlike similarly treated wild-type mice

abnormal papillary duct morphology ( J:163552 )

• occasionally, large plugging crystals are detected within the ducts of Bellini

dilated kidney collecting duct ( J:127526 , J:163552 )

• in some mice after 1 month of hyperoxaluria (J:127526)

• when occasional large crystals are found within the ducts of Bellini, adjacent collecting tubules are markedly dilated (J:163552)

abnormal kidney papilla morphology ( J:163552 )

• male mice develop progressive renal papillary calcification, unlike wild-type controls

hydronephrosis ( J:163552 )

• at 5-8 months of age, 3 of 20 male mice exhibit hydronephrosis

• by 15 months of age, 5 of 16 male mice exhibit hydronephrosis with increased severity

• both unilateral and bilateral hydronephrosis are observed

nephrocalcinosis ( J:127526 , J:163552 )

• 14% of mice exhibit calcifications in the renal papilla unlike wild-type mice (J:127526)

• renal epithelial cells exhibit a 2-fold increase in crystal adhesion to epithelial cells compared with wild-type cells (J:127526)

• 71% of mice exposed to hyperoxaluria develop renal calcinosis unlike similarly treated wild-type mice (J:127526)

• by 5-8 months of age, ~50% of male mice analyzed develop spontaneous renal papillary calcinosis, not observed in wild-type controls; the frequency of crystal deposition in the renal papilla increases to 87.5% by 15 months of age (J:163552)

• at 5-8 months , both intratubular (26.1%) and interstitial calcium crystals (73.9%) are present, while interstitial crystals are even more common (93.2%) by 15 months of age (J:163552)

• papillary interstitial crystals are located primarily beneath the tubular cells of the collecting ducts, and consist of calcium phosphate (hydroxyapatite) and a small amount of calcium carbonate (J:163552)

• the extent of crystal formation varies from tubule to tubule, from small crystals spanning the length of 2-3 tubular cells to large crystals spanning up to 10-15 cells (J:163552)

• no macrophage infiltration is observed in the vicinity of interstitial crystals (J:163552)

• no crystals are detected in the cortex and outer medulla (J:163552)

renal fibrosis ( J:127526 )

• following hyperoxaluria, mice exhibit greater renal damage and fibrosis than similarly treated wild-type mice

urolithiasis ( J:163552 )

• most hydronephrotic mice exhibit stone-like structures in the ureter and renal pelvis

decreased urine flow rate ( J:163552 )

• at 5-8 months of age, mice exhibit a significantly lower 24-hr urinary volume than wild-type controls

homeostasis/metabolism

abnormal urine homeostasis ( J:127526 , J:163552 )

• at 5-8 months of age, the concentrations of Cl, K, Ca, Mg, P, uric acid, creatinine, and ammonium are nearly doubled relative to wild-type controls (J:163552)

• at 5-8 months of age, mice exhibit urinary supersaturation of calcium phosphate (brushite), uric acid and sodium urate, but not calcium oxalate (J:163552)

increased urine creatinine level ( J:163552 )

increased urine ammonia level ( J:163552 )

increased urine chloride ion level ( J:127526 , J:163552 )

• urine chloride ion levels are higher than in wild-type mice (J:127526)

increased urine potassium level ( J:163552 )

increased urine sodium level ( J:127526 )

abnormal urine organic anion level ( J:163552 )

• at 5-8 months of age, the concentrations of organic anions such as citrate and oxalate are slightly lower than in wild-type controls

decreased urine citrate level ( J:163552 )

• at 5-8 months of age, the concentrations of citrate are slightly lower than in wild-type controls

increased urine calcium level ( J:163552 )

increased urine magnesium level ( J:163552 )

decreased urine pH ( J:163552 )

• at 5-8 months of age, urine pH is significantly lower than that in wild-type controls

increased urine phosphate level ( J:127526 , J:163552 )

• urine phosphorus and calcium phosphate levels are higher than in wild-type mice (J:127526)

increased urine uric acid level ( J:163552 )

crystalluria ( J:127526 )

• under hyperoxaluria conditions, 71% of mice exhibit moderate amounts of calcium crystalluria and renal calcium crystal formation unlike similarly treated wild-type mice

• following hyperoxaluria, mice develop stones unlike similarly treated wild-type mice

Allelic Composition	Umod^tm1Xrw/Umod^tm1Xrw
Genetic Background	B6.129S6-Umod^tm1Xrw

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Umod^tm1Xrw mutation (0 available); any Umod mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal papillary duct morphology ( J:163552 )

• occasionally, large plugging crystals are detected within the ducts of Bellini

dilated kidney collecting duct ( J:163552 )

• when occasional large crystals are found within the ducts of Bellini, adjacent collecting tubules are markedly dilated

abnormal kidney papilla morphology ( J:163552 )

• mice of both sexes develop progressive renal papillary calcification, unlike wild-type controls

hydronephrosis ( J:163552 )

• at 5-8 months of age, 2 of 9 male mice and 1 of 11 female mice exhibit hydronephrosis

• by 15 months of age, 7 of 11 male mice and 2 of 2 female mice exhibit hydronephrosis with increased severity

• both unilateral and bilateral hydronephrosis are observed

nephrocalcinosis ( J:163552 )

• by 5-8 months of age, ~50% of mice (both sexes analyzed) develop spontaneous renal papillary calcinosis, not observed in wild-type controls; the frequency of crystal deposition in the renal papilla increases to 100% in both sexes by 15 months of age

• at 5-8 months, both intratubular (26.1%) and interstitial calcium crystals (73.9%) are present, while interstitial crystals are even more common (93.2%) by 15 months of age

• papillary interstitial crystals are located primarily beneath the tubular cells of the collecting ducts, and consist of calcium phosphate (hydroxyapatite) and a small amount of calcium carbonate

• the extent of crystal formation varies from tubule to tubule, from small crystals spanning the length of 2-3 tubular cells to large crystals spanning up to 10-15 cells

• no macrophage infiltration is observed in the vicinity of interstitial crystals

• no crystals are detected in the cortex and outer medulla

urolithiasis ( J:163552 )

• most hydronephrotic mice exhibit stone-like structures in the ureter and renal pelvis

Allelic Composition	Umod^tm1Xrw/Umod^tm1Xrw
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Umod^tm1Xrw mutation (0 available); any Umod mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to bacterial infection ( J:95431 )

• intravesicular inoculation of type 1-fimbriated E.coli, but not type P-fimbriated E.coli, caused significantly greater bladder colonization than in controls, indicating susceptibility to bladder infection by type 1-fimbriated E.coli

Allelic Composition	Umod^tm1Xrw/Umod⁺
Genetic Background	B6.129S6-Umod^tm1Xrw

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Umod^tm1Xrw mutation (0 available); any Umod mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

hydronephrosis ( J:163552 )

• at 5-8 months of age, 2 of 18 male mice but none of 8 female mice exhibit hydronephrosis

• by 15 months of age, 3 of 4 male mice and 1 of 3 female mice exhibit hydronephrosis with increased severity

• both unilateral and bilateral hydronephrosis are observed

nephrocalcinosis ( J:163552 )

• at 5-8 months of age, 33.3% of male and 25% of female mice exhibit spontaneous renal papillary calcinosis

• by 15 months of age, 75% of male and 33.3% of female mice develop renal papillary calcium crystallization

urolithiasis ( J:163552 )

• most hydronephrotic mice exhibit stone-like structures in the ureter and renal pelvis

Allelic Composition	Spp1^tm1Blh/Spp1^tm1Blh Umod^tm1Xrw/Umod^tm1Xrw
Genetic Background	129S/SvEv-Spp1^tm1Blh Umod^tm1Xrw

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1^tm1Blh mutation (2 available); any Spp1 mutation (40 available)
Umod^tm1Xrw mutation (0 available); any Umod mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

increased urine phosphate level ( J:127526 )

• urine phosphorus and calcium phosphate content are higher than in wild-type mice

increased urine uric acid level ( J:127526 )

crystalluria ( J:127526 )

• under hyperoxaluria conditions, 95% of mice exhibit large amounts of calcium crystalluria and renal calcium crystal formation unlike similarly treated wild-type mice

• after 1 month of hyperoxaluria, 18% of mice develop large crystalline deposits at the tip of the renal papillae that can block the proximal portions of the collecting ducts unlike similarly treated wild-type mice

• following hyperoxaluria, mice develop stones unlike similarly treated wild-type mice

dilated kidney collecting duct ( J:127526 )

• in some mice after 1 month of hyperoxaluria

nephrocalcinosis ( J:127526 )

• 95% of mice exposed to hyperoxaluria develop renal calcinosis unlike similarly treated wild-type mice

• 39% of mice exhibit calcifications in the renal papilla unlike wild-type mice

• renal epithelial cells exhibit a 3.5-fold increase in crystal adhesion to epithelial cells compared with wild-type cells

renal fibrosis ( J:127526 )

• following hyperoxaluria, mice exhibit greater renal damage and fibrosis than similarly treated wild-type mice

homeostasis/metabolism

increased urine phosphate level ( J:127526 )

• urine phosphorus and calcium phosphate content are higher than in wild-type mice

increased urine uric acid level ( J:127526 )

crystalluria ( J:127526 )

• under hyperoxaluria conditions, 95% of mice exhibit large amounts of calcium crystalluria and renal calcium crystal formation unlike similarly treated wild-type mice

• following hyperoxaluria, mice develop stones unlike similarly treated wild-type mice

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