Phenotypes associated with this allele

• Allele Symbol: Sim1^tm1.1Az
• Allele Name: targeted mutation 1.1, Andrew R Zinn
• Allele ID: MGI:3526899
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Sim1^tm1.1Az/Sim1^+	involves: 129X1/SvJ * C57BL/6 * FVB	MGI:3527276

Genotype
MGI:3527276

ht1

• Allelic Composition: Sim1^tm1.1Az/Sim1⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:95410 )

• percent body fat was increased, with females more severely affected

behavior/neurological

polyphagia ( J:95410 )

• on a low fat diet, consumed 14% more food per day than controls

• on a high fat diet, males consumed 46% more than controls

• three- to fourfold increase in the percent difference in food intake of heterozyogotes versus controls fed the high versus the low fat diet

growth/size/body

increased body weight ( J:95410 )

• males had more than twice as much fat mass as controls and females had more than tree times as much

• lean mass of both males and females was increased by more than 20%

obese ( J:95410 )

• 8 week old females weighed 13% and 71% more than controls fed a low fat and high fat diet, respectively

• 8 week old males weighed 22% and 51% more than controls fed a low fat and high fat diet, respectively

• continued to gain weight until more than 6 months of age on the low fat diet and 4 months of age on the high fat diet

increased body length ( J:95410 )

• heterozygotes fed either a low or high fat diet were longer than wild-type

increased susceptibility to diet-induced obesity ( J:95410 )

• males consumed 46% more food on a high fat diet than controls and became obese

homeostasis/metabolism

increased circulating glucose level ( J:95410 )

• female, but not male, heterozygotes weaned onto the high fat diet had slightly increased serum glucose levels compared to controls, however no differences in glucose levels on the low fat diet

increased circulating insulin level ( J:95410 )

• heterozygotes weaned on the low fat diet had higher serum insulin levels, however young (6-8 week old) mice had normal levels

increased circulating leptin level ( J:95410 )

• serum leptin levels were elevated in both males and females fed the low fat diet

abnormal energy homeostasis ( J:95410 )

• heterozygous males had 2.5 or 1.9-fold greater feeding efficiency (weight gained per kilocalorie ingested) than controls fed the low fat or high fat diet, respectively

• heterozygous females had 2 or 3-fold greater feeding efficiency than controls fed the low fat or high fat diet, respectively

• increased energy consumption by 57% (males) or 49% (females) when shifted from low fat to high fat diet compared to a 20% increase in controls

increased susceptibility to diet-induced obesity ( J:95410 )

• males consumed 46% more food on a high fat diet than controls and became obese