Analysis Tools
mortality/aging
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• homozygotes die at approximately E10.5, with no homozygotes found at E11.5
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cardiovascular system
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• trabeculation of the bulbus cordis and the common ventricular chamber is highly disorganized at E10.5
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• the spiral septum of the outflow tract displays little or no septal development at E10.5
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• E10.5 homozygotes exhibit abnormal heart development
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• little evidence of the formation of the endocardial cushion tissue in the atroventricular canal
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cellular
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• the head, heart and dorsal regions of E10.5 embryos exhibit an increase in apoptosis, with increased apoptosis observed as early as E9.5
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• the head, heart, and dorsal regions of E10.5 embryos exhibit a decrease in cell proliferation, however observe no effect on cell cycle progression
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embryo
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• severely retarded growth especially of the heart, head and limbs
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growth/size/body
muscle
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• trabeculation of the bulbus cordis and the common ventricular chamber is highly disorganized at E10.5
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