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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Flt1tm2Msh
targeted mutation 2, Masabumi Shibuya
MGI:3527129
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Flt1tm2Msh/Flt1tm2Msh B6.129S-Flt1tm2Msh MGI:3527541
hm2
 		Flt1tm2Msh/Flt1tm2Msh involves: 129S/SvEv * C57BL/6J MGI:3527538
ht3
 		Flt1tm2Msh/Flt1+ involves: 129S/SvEv * C57BL/6J MGI:3527539
cx4
 		Flt1tm2Msh/Flt1tm2Msh
Kdrtm1Jrt/Kdr+ 		involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3527542
cx5
 		Flt1tm2Msh/Flt1tm2Msh
Kdrtm1Jrt/Kdrtm1Jrt 		involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3527543


Genotype
MGI:3527541
hm1
Allelic
Composition		 Flt1tm2Msh/Flt1tm2Msh
Genetic
Background		 B6.129S-Flt1tm2Msh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1tm2Msh mutation (1 available); any Flt1 mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:95387 )
• almost all homozygous embryos survive




Genotype
MGI:3527538
hm2
Allelic
Composition		 Flt1tm2Msh/Flt1tm2Msh
Genetic
Background		 involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1tm2Msh mutation (1 available); any Flt1 mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:95387 )
• about 50% of homozygotes die around E9.5; the other half survive and develop normally

cardiovascular system
abnormal vascular endothelial cell morphology ( J:95387 )
• increased endothelial cell apoptosis is seen
abnormal vascular development ( J:95387 )
• poor blood vessel formation is seen in about 50% of homozygous embryos
abnormal dorsal aorta morphology ( J:95387 )
• the dorsal aorta in growth retarded embryos is smaller than norma

embryo
abnormal embryo turning ( J:95387 )
• about 50% of embryos fail to turn by E8.5
embryonic growth arrest ( J:95387 )
• about 50% of embryos display growth arrest before E8.5




Genotype
MGI:3527539
ht3
Allelic
Composition		 Flt1tm2Msh/Flt1+
Genetic
Background		 involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1tm2Msh mutation (1 available); any Flt1 mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal embryo development ( J:95387 )
• about 50% of embryos show developmental defects similar to those in homozygous mice




Genotype
MGI:3527542
cx4
Allelic
Composition		 Flt1tm2Msh/Flt1tm2Msh
Kdrtm1Jrt/Kdr+
Genetic
Background		 involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1tm2Msh mutation (1 available); any Flt1 mutation (76 available)
Kdrtm1Jrt mutation (1 available); any Kdr mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:95387 )
• about 90% of mutants die as embryos

cardiovascular system
abnormal vascular endothelial cell differentiation ( J:95387 )
• differentiation of vascular endothelial cells is disturbed
abnormal vascular endothelial cell migration ( J:95387 )
• Kdr+ cells (lacZ expressing) abnormally accumulate in the middle to posterior portion of the embryo

cellular
abnormal vascular endothelial cell differentiation ( J:95387 )
• differentiation of vascular endothelial cells is disturbed
abnormal vascular endothelial cell migration ( J:95387 )
• Kdr+ cells (lacZ expressing) abnormally accumulate in the middle to posterior portion of the embryo




Genotype
MGI:3527543
cx5
Allelic
Composition		 Flt1tm2Msh/Flt1tm2Msh
Kdrtm1Jrt/Kdrtm1Jrt
Genetic
Background		 involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt1tm2Msh mutation (1 available); any Flt1 mutation (76 available)
Kdrtm1Jrt mutation (1 available); any Kdr mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality ( J:95387 )
• all of the double homozygotes die as embryos

cardiovascular system
abnormal vascular endothelial cell migration ( J:95387 )
• Kdr+ cells (lacZ expressing) abnormally accumulate in the posterior portion of the embryo

cellular
abnormal vascular endothelial cell migration ( J:95387 )
• Kdr+ cells (lacZ expressing) abnormally accumulate in the posterior portion of the embryo




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory