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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Arr3tm1Chcr
targeted mutation 1, Cheryl M Craft
MGI:3527130
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Arr3tm1Chcr/Arr3tm1Chcr involves: 129S/SvEv * C57BL/6 MGI:3810254
cx2
 		Arr3tm1Chcr/Arr3tm1Chcr
Sagtm1Jnc/Sagtm1Jnc 		involves: 129S/SvEv * C57BL/6 MGI:3810255


Genotype
MGI:3810254
hm1
Allelic
Composition		 Arr3tm1Chcr/Arr3tm1Chcr
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arr3tm1Chcr mutation (0 available); any Arr3 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:139694 )
N
• mice exhibit normal cone electrophysiology




Genotype
MGI:3810255
cx2
Allelic
Composition		 Arr3tm1Chcr/Arr3tm1Chcr
Sagtm1Jnc/Sagtm1Jnc
Genetic
Background		 involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arr3tm1Chcr mutation (0 available); any Arr3 mutation (11 available)
Sagtm1Jnc mutation (9 available); any Sag mutation (44 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal cone electrophysiology ( J:139694 )
• cones exhibit a greatly slowed recovery from strong flashes compared to wild-type cones
• the amplitude of slow tails of recovery are increased compared to in wild-type mice
• S- and M-cone opsin driven dim-flash responses exhibit slow tail in recovery unlike wild-type mice
• however, the peak time of dim-flash response is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory