Phenotypes associated with this allele

• Allele Symbol: Smad2^{tm4(SMADH3)Rob}
• Allele Name: targeted mutation 4, Elizabeth J Robertson
• Allele ID: MGI:3527156
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smad2^tm4(SMADH3)Rob/Smad2^tm4(SMADH3)Rob	involves: 129S/SvEv * C57BL/6 * ICR	MGI:3527580

Genotype
MGI:3527580

hm1

• Allelic Composition: Smad2^{tm4(SMADH3)Rob}/Smad2^{tm4(SMADH3)Rob}
• Genetic Background: involves: 129S/SvEv * C57BL/6 * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:95374 )

• about 50% homozygous embryos die in utero or at birth

prenatal lethality, incomplete penetrance ( J:95374 )

• about 50% homozygous embryos die in utero or at birth

nervous system

abnormal forebrain development ( J:95374 )

• at E15.5-E16.5 some homozygotes displayed limited forebrain development

abnormal hindbrain development ( J:95374 )

• at E15.5-E16.5 some homozygotes displayed limited hindbrain development

holoprosencephaly ( J:95374 )

• some homozygotes display holoprosencephaly

exencephaly ( J:95374 )

• some homozygotes display exencephaly

growth/size/body

microcephaly ( J:95374 )

• some homozygotes display microcephaly