Phenotypes associated with this allele

• Allele Symbol: Drd1^tm2Rpa
• Allele Name: targeted mutation 1, Richard D Palmiter
• Allele ID: MGI:3527157
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Drd1^tm2Rpa/Drd1^tm2Rpa	involves: 129S4/SvJae * C57BL/6 * C57BL/6J	MGI:3717613

Genotype
MGI:3717613

hm1

• Allelic Composition: Drd1^tm2Rpa/Drd1^tm2Rpa
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired behavioral response to cocaine ( J:121750 )

• following treatment with cocaine for 5 days, mice do not show increased locomoter activity as seen in wild-type mice

impaired conditioned place preference behavior ( J:121750 )

• however, place preference matched wild-type response when a dose of 30 mg/kg cocaine is used

• using 20 mg/kg of cocaine, mice do not present preference for drug side in a place conditioning assay