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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Grin1tm1Rpa
targeted mutation 1, Richard D Palmiter
MGI:3527183
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Grin1tm1Rpa/Grin1tm1.1Rpa Not Specified MGI:3835419
cn2
 		Grin1tm1Rpa/Grin1tm1.1Rpa
Slc6a3tm1(cre)Xz/Slc6a3+ 		involves: 129S1/Sv MGI:3835418


Genotype
MGI:3835419
cn1
Allelic
Composition		 Grin1tm1Rpa/Grin1tm1.1Rpa
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1.1Rpa mutation (0 available); any Grin1 mutation (66 available)
Grin1tm1Rpa mutation (0 available); any Grin1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal excitatory postsynaptic currents ( J:145468 )
• the NMDAR excitatory postsynaptic currents (EPSC)s of mice injected with an adenovirus cre into the ventral tegmental area at 3 weeks of age are decreased compared to in wild-type mice
abnormal miniature excitatory postsynaptic currents ( J:145468 )
• in mice injected with an adenovirus cre into the ventral tegmental area at 3 weeks of age, the miniature excitatory postsynaptic currents (EPSCs) of dopaminergic neurons are increased in amplitude and frequency compared to in dopaminergic neurons not transfected with adenoviral cre

behavior/neurological
impaired conditioned place preference behavior ( J:145468 )
• mice injected with an adenovirus cre into the ventral tegmental area at 3 weeks of age fail to display conditioned place preference for cocaine compared to mice with cre activation in less than 50% of TH neurons
• however, mice injected with an adenovirus cre into the ventral tegmental area at 3 weeks of age exhibit normal locomotor-stimulating effects of drugs




Genotype
MGI:3835418
cn2
Allelic
Composition		 Grin1tm1Rpa/Grin1tm1.1Rpa
Slc6a3tm1(cre)Xz/Slc6a3+
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grin1tm1.1Rpa mutation (0 available); any Grin1 mutation (66 available)
Grin1tm1Rpa mutation (0 available); any Grin1 mutation (66 available)
Slc6a3tm1(cre)Xz mutation (2 available); any Slc6a3 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal excitatory postsynaptic currents ( J:145468 )
• mice lack the NMDAR component of the excitatory postsynaptic current (EPSC) in dopaminergic neurons unlike in wild-type mice
• AMPA-evoked EPSCs are increased compared to wild-type mice
• however, NMDAR-mediated EPSCs in non-dopaminergic neurons are normal
reduced long-term potentiation ( J:145468 )
• absent in dopaminergic neurons
abnormal miniature excitatory postsynaptic currents ( J:145468 )
• miniature excitatory postsynaptic current (EPSC) are increased in amplitude and frequency compared to in similarly treated wild-type mice that is identical to the increase observed in mice treated with cocaine

behavior/neurological
abnormal behavioral response to addictive substance ( J:145468 )
• 21 days after cocaine withdrawal mice fail to exhibit significant enhancement of behavioral sensitization
• however, mice exhibit normal locomotor-stimulating effects of drugs
impaired conditioned place preference behavior ( J:145468 )
• mice fail to exhibit conditioned place preference for cocaine
• however, mice exhibit normal conditioned place aversion to naloxone




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory