Phenotypes associated with this allele

• Allele Symbol: Ctsk^tm1Vuo
• Allele Name: targeted mutation 1, Eero Vuorio
• Allele ID: MGI:3527195
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctsk^tm1Vuo/Ctsk^tm1Vuo	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3527897

Genotype
MGI:3527897

hm1

• Allelic Composition: Ctsk^tm1Vuo/Ctsk^tm1Vuo
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal osteoclast morphology ( J:95525 )

• the osteoclast surface area is doubled

increased osteoclast cell number ( J:95525 )

• the number of osteoclasts and osteoclast precursors are increased

increased bone mineral density ( J:95525 )

• total and trabecular bone mineral density are increased at 2 months of age; however, this difference decreases with age

abnormal trabecular bone morphology ( J:95525 )

• trabecular bone volume and thickness and trabecular number are increased and trabecular separation is decreased in homozygotes

osteopetrosis ( J:95525 )

• in the metaphyseal and diaphyseal region of the femur and tibia cartical thickness is increased at 2 months of age but does not increase more with age

hematopoietic system

abnormal osteoclast morphology ( J:95525 )

• the osteoclast surface area is doubled

increased osteoclast cell number ( J:95525 )

• the number of osteoclasts and osteoclast precursors are increased

immune system

abnormal osteoclast morphology ( J:95525 )

• the osteoclast surface area is doubled

increased osteoclast cell number ( J:95525 )

• the number of osteoclasts and osteoclast precursors are increased