Phenotypes associated with this allele

• Allele Symbol: Cd276^tm1Wwh
• Allele Name: targeted mutation 1, Wayne W Hancock
• Allele ID: MGI:3527215
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd276^tm1Wwh/Cd276^tm1Wwh	B6.Cg-B7h3^tm1Wwh	MGI:3527895

Genotype
MGI:3527895

hm1

• Allelic Composition: Cd276^tm1Wwh/Cd276^tm1Wwh
• Genetic Background: B6.Cg-B7h3^tm1Wwh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal cytokine secretion ( J:95550 )

• cyclosporin A and rapamycin treatment result in decreased expression of IL-2, IFNG, and decreased expression of chemokines CCL2 and CXCL10 in engrafted homozygotes compared to similarly treated wild-type mice

abnormal response to transplant ( J:95550 )

• about 50% of homozygotes given a subtherapeutic regimen of cyclosporin A survive over 30 days longer after transplantation of hearts from BALB/c donors unlike wild-type mice which survive only 1-2 days longer with cyclosporin A treatment

• rapamycin therapy led to permanent cardiac allograft engraftment and in about 70% of homozygotes permanent islet allograft engraftment, unlike in wild-type mice where rapamycin treatment resulted in a maximum increase in survival of 12 days (cardiac) or 2 weeks (islet)

• homozygous mutants that receive cardiac allografts with CD154 mAb treatment survive indefinitely while wild-type mice display end-stage rejection at 50 days post-transplant

• in a model of MHC class II disparity homozygotes do not display severe transplant arteriosclerosis or interstitial fibrosis unlike wild-type mice