Phenotypes associated with this allele

• Allele Symbol: Akr1c18^tm1Jni
• Allele Name: targeted mutation 1, James N Ihle
• Allele ID: MGI:3527218
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Akr1c18^tm1Jni/Akr1c18^tm1Jni	involves: 129P2/OlaHsd * C57BL/6	MGI:3527340
cx2	Akr1c18^tm1Jni/Akr1c18^tm1Jni Stat5b^tm1Hwd/Stat5b^tm1Hwd	involves: 129P2/OlaHsd * C57BL/6	MGI:3527341

Genotype
MGI:3527340

hm1

• Allelic Composition: Akr1c18^tm1Jni/Akr1c18^tm1Jni
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

long gestation period ( J:95560 )

♀

parturition failure ( J:95560 )

♀ • failure to induce parturition normally

♀ • due to a delayed drop in progesterone levels

♀ • results in death of pups

behavior/neurological

behavior/neurological phenotype ( J:95560 )

N • unexpectedly, nursing behavior was normal

hematopoietic system

hematopoietic system phenotype ( J:95560 )

N • unexpectedly, hematopoiesis was normal

Genotype
MGI:3527341

cx2

• Allelic Composition: Akr1c18^tm1Jni/Akr1c18^tm1Jni; Stat5b^tm1Hwd/Stat5b^tm1Hwd
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

reproductive system

reproductive system phenotype ( J:95560 )

N • corrected mid gestation abortion of embryos seen in Stat5b^tm1Hwd homozygotes