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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dok2tm1Ppp
targeted mutation 1, Pier Paolo Pandolfi
MGI:3527246
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dok2tm1Ppp/Dok2tm1Ppp 129S1/Sv-Dok2tm1Ppp MGI:3574542
ht2
Dok2tm1Ppp/Dok2+ 129S1/Sv-Dok2tm1Ppp MGI:4443012
cx3
Dok1tm1Ppp/Dok1tm1Ppp
Dok2tm1Ppp/Dok2tm1Ppp
129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp MGI:3574543
cx4
Dok1tm1Ppp/Dok1tm1Ppp
Dok2tm1Ppp/Dok2tm1Ppp
Dok3tm1Ppp/Dok3tm1Ppp
129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp MGI:4443009
cx5
Dok2tm1Ppp/Dok2tm1Ppp
Tg(Tec-BCR/ABL1)5Hhi/0
involves: 129S1/Sv MGI:3574544
cx6
Dok2tm1Ppp/Dok2+
Tg(Tec-BCR/ABL1)5Hhi/0
involves: 129S1/Sv MGI:3574546


Genotype
MGI:3574542
hm1
Allelic
Composition
Dok2tm1Ppp/Dok2tm1Ppp
Genetic
Background
129S1/Sv-Dok2tm1Ppp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok2tm1Ppp mutation (0 available); any Dok2 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• activation of granulocytes by TPA is impaired but no increase in spontaneous infections is seen

neoplasm
• at 11-25 months, 24% of mice develop lung adenocarcinoma compared with 7% of wild-type mice

hematopoietic system
• activation of granulocytes by TPA is impaired but no increase in spontaneous infections is seen

respiratory system
• at 11-25 months, 24% of mice develop lung adenocarcinoma compared with 7% of wild-type mice




Genotype
MGI:4443012
ht2
Allelic
Composition
Dok2tm1Ppp/Dok2+
Genetic
Background
129S1/Sv-Dok2tm1Ppp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok2tm1Ppp mutation (0 available); any Dok2 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• at 15 to 19 months, 4 of 12 mice develop lung tumors unlike wild-type mice

respiratory system
• at 15 to 19 months, 4 of 12 mice develop lung tumors unlike wild-type mice




Genotype
MGI:3574543
cx3
Allelic
Composition
Dok1tm1Ppp/Dok1tm1Ppp
Dok2tm1Ppp/Dok2tm1Ppp
Genetic
Background
129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Ppp mutation (0 available); any Dok1 mutation (19 available)
Dok2tm1Ppp mutation (0 available); any Dok2 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• double homozygotes develop chronic myeloid leukemia-like myeloproliferative disease at 10-12 months of age
• this myeloproliferative disease is fully transplantable
• at 11-25 months, 32% of mice develop lung compared with 7% of wild-type mice adenocarcinoma

hematopoietic system
• bone marrow hypercellularity and infiltration by myeloid cells that retain the ability to terminally differentiate are seen
• a progressive increase in WBC numbers in the peripheral blood is seen after 4 months of age
• infiltration by myeloid cells that retain the ability to terminally differentiate is seen
• myeloid bone marrow cells display increased proliferation in response to growth factors and in the absence of growth factors and attenuated apoptosis when deprived of growth factors

immune system
• a progressive increase in WBC numbers in the peripheral blood is seen after 4 months of age
• infiltration by myeloid cells that retain the ability to terminally differentiate is seen
• myeloid bone marrow cells display increased proliferation in response to growth factors and in the absence of growth factors and attenuated apoptosis when deprived of growth factors

respiratory system
• at 11-25 months, 32% of mice develop lung compared with 7% of wild-type mice adenocarcinoma

growth/size/body

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
chronic myeloid leukemia DOID:8552 OMIM:608232
J:95334




Genotype
MGI:4443009
cx4
Allelic
Composition
Dok1tm1Ppp/Dok1tm1Ppp
Dok2tm1Ppp/Dok2tm1Ppp
Dok3tm1Ppp/Dok3tm1Ppp
Genetic
Background
129S1/Sv-Dok1tm1Ppp Dok2tm1Ppp Dok3tm1Ppp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Ppp mutation (0 available); any Dok1 mutation (19 available)
Dok2tm1Ppp mutation (0 available); any Dok2 mutation (16 available)
Dok3tm1Ppp mutation (0 available); any Dok3 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice begin to die at around 1 year of age unlike wild-type mice

respiratory system
• mice exhibit an increase in the total number of lung cells compared with wild-type mice
• however, lung weight is normal
• at 6 weeks, 30% of mice develop small lung tumors unlike wild-type mice
• at 11-25 months, 64% of mice develop lung adenocarcinoma compared with 7% of wild-type mice
• the number and percentages of bronchioalveolar stem cells are increased compared to in wild-type mice
• at 12 weeks, mice exhibit alveolar hyperplasia with scattered bronchioaveolar stem cells unlike in wild-type mice
• the number and percentages of alveolar type 2 cells are increased compared to in wild-type mice

neoplasm
• at 20 months, mice exhibit an expansion of Mac-1+ and GR-1+ Mac-1+ cells compared with wild-type mice
• however, Mac-1+ and GR-1+ Mac-1+ cell numbers are normal at 3 months
• at 6 weeks, 30% of mice develop small lung tumors unlike wild-type mice
• at 11-25 months, 64% of mice develop lung adenocarcinoma compared with 7% of wild-type mice

immune system

hematopoietic system

growth/size/body
• mice exhibit an increase in the total number of lung cells compared with wild-type mice
• however, lung weight is normal




Genotype
MGI:3574544
cx5
Allelic
Composition
Dok2tm1Ppp/Dok2tm1Ppp
Tg(Tec-BCR/ABL1)5Hhi/0
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok2tm1Ppp mutation (0 available); any Dok2 mutation (16 available)
Tg(Tec-BCR/ABL1)5Hhi mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• loss of Dok2 shortened lifespan to about 270 days from about 321 days in mice that are hemizygous for Tg(BCR/ABL1)5Hhi and wild-type for Dok2

neoplasm
• inactivation of Dok2 accelerated the onset of the chronic phase and the fatal blastic phase

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
chronic myeloid leukemia DOID:8552 OMIM:608232
J:95334




Genotype
MGI:3574546
cx6
Allelic
Composition
Dok2tm1Ppp/Dok2+
Tg(Tec-BCR/ABL1)5Hhi/0
Genetic
Background
involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok2tm1Ppp mutation (0 available); any Dok2 mutation (16 available)
Tg(Tec-BCR/ABL1)5Hhi mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• loss of Dok2 shortened lifespan to about 283 days from about 321 days in mice that are hemizygous for Tg(BCR/ABL1)5Hhi and wild-type for Dok2

neoplasm
• inactivation of Dok2 accelerated the onset of the chronic phase and the fatal blastic phase
• acceleration was not as severe as in homozygous null mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
chronic myeloid leukemia DOID:8552 OMIM:608232
J:95334





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory