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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rad50tm1Flv
targeted mutation 1, Richard A Flavell
MGI:3527268
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Rad50tm1Flv/Rad50tm1Flv involves: 129S6/SvEvTac * C57BL/6 MGI:4430414


Genotype
MGI:4430414
hm1
Allelic
Composition		 Rad50tm1Flv/Rad50tm1Flv
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50tm1Flv mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T-helper 2 physiology ( J:94870 )
• following immunization in vivo, splenocytes produce less TH2 cytokines (IL4, IL5, and IL13) compared with cells from similarly treated wild-type mice
decreased interleukin-13 secretion ( J:94870 )
• from splenocytes following immunization in vivo
decreased interleukin-4 secretion ( J:94870 )
• from splenocytes following immunization in vivo
decreased interleukin-5 secretion ( J:94870 )
• from splenocytes following immunization in vivo

hematopoietic system
abnormal T-helper 2 physiology ( J:94870 )
• following immunization in vivo, splenocytes produce less TH2 cytokines (IL4, IL5, and IL13) compared with cells from similarly treated wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory