About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dok2tm1Yyam
targeted mutation 1, Yuji Yamanashi
MGI:3527416
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam 		B6.129-Dok1tm1Yyam Dok2tm1Yyam MGI:3574536
cx2
 		Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:4829895
cx3
 		Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Dok3tm1Brs/Dok3tm1Brs 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:4829896
cx4
 		Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Tg(Tec-BCR/ABL1)5Hhi/0 		involves: C57BL/6 MGI:3574538
cx5
 		Dok2tm1Yyam/Dok2tm1Yyam
Tg(Tec-BCR/ABL1)5Hhi/0 		involves: C57BL/6 MGI:3574539


Genotype
MGI:3574536
cx1
Allelic
Composition		 Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Genetic
Background		 B6.129-Dok1tm1Yyam Dok2tm1Yyam
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (19 available)
Dok2tm1Yyam mutation (0 available); any Dok2 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased leukemia incidence ( J:95335 )
• double homozygotes develop myeloproliferative disease by about 1 year of age with atypical myeloid cells resembling myelomonocytic cells
• cellular infiltrations of granulocytes and lymphocytes are seen in several tissues
increased sarcoma incidence ( J:95335 )
• about half of the double homozygotes with myeloproliferative disease develop histiocytic sarcoma of macrophage origin

hematopoietic system
enlarged spleen ( J:95335 )
• at about 1 year of age double homozygotes have enlarged spleens where immature and mature granulocytes/monocytes, erythroblasts, and atypical myeloid cells accumulate
abnormal myelopoiesis ( J:95335 )
• bone marrow and spleen have an increased ratio of immature granulocytic and/or monocytic precursors
• hyperplasia of myeloid precursors
increased megakaryocyte cell number ( J:95335 )
• hyperplasia of megakaryocytes
increased erythroblast number ( J:95335 )
• hyperplasia of erythroblasts
increased leukocyte cell number ( J:95335 )
• leukocyte numbers in the peripheral blood are significantly higher
abnormal leukocyte physiology ( J:95335 )
• at 8 weeks of age bone marrow derived mast cells display increased proliferation in response to cytokines and attenuated apoptosis when deprived of cytokines

immune system
enlarged spleen ( J:95335 )
• at about 1 year of age double homozygotes have enlarged spleens where immature and mature granulocytes/monocytes, erythroblasts, and atypical myeloid cells accumulate
abnormal myelopoiesis ( J:95335 )
• bone marrow and spleen have an increased ratio of immature granulocytic and/or monocytic precursors
• hyperplasia of myeloid precursors
increased leukocyte cell number ( J:95335 )
• leukocyte numbers in the peripheral blood are significantly higher
abnormal leukocyte physiology ( J:95335 )
• at 8 weeks of age bone marrow derived mast cells display increased proliferation in response to cytokines and attenuated apoptosis when deprived of cytokines

growth/size/body
enlarged spleen ( J:95335 )
• at about 1 year of age double homozygotes have enlarged spleens where immature and mature granulocytes/monocytes, erythroblasts, and atypical myeloid cells accumulate

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
chronic myeloid leukemia DOID:8552 OMIM:608232
 J:95335




Genotype
MGI:4829895
cx2
Allelic
Composition		 Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (19 available)
Dok2tm1Yyam mutation (0 available); any Dok2 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:163407 )
• bone marrow-derived macrophages at 10-12 weeks of age stimulated with M-CSF and GM-CSF, show an increased proliferative response compared to wild-type

hematopoietic system
abnormal macrophage physiology ( J:163407 )
• bone marrow-derived macrophages at 10-12 weeks of age stimulated with M-CSF and GM-CSF, show an increased proliferative response compared to wild-type




Genotype
MGI:4829896
cx3
Allelic
Composition		 Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Dok3tm1Brs/Dok3tm1Brs
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (19 available)
Dok2tm1Yyam mutation (0 available); any Dok2 mutation (16 available)
Dok3tm1Brs mutation (0 available); any Dok3 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:163407 )
• nearly half (15 of 33) of the mice died between 14?51 weeks after birth

neoplasm
increased tumor incidence ( J:163407 )
• a markedly high incidence (24 of 41) of large cell tumors at 65 weeks of age
increased histiocytic sarcoma incidence ( J:163407 )
• abnormal proliferative cells with histiocytic morphology and cell surface markers in the bone marrow, spleen, and/or liver
• the histiocytic sarcoma is highly invasive and transplantable

hematopoietic system
increased macrophage cell number ( J:163407 )
• abnormal Mac-2-positive macrophages in the lung
abnormal macrophage physiology ( J:163407 )
• bone marrow-derived macrophages at 10-12 weeks of age stimulated with M-CSF and GM-CSF, show an increased proliferative response

immune system
increased macrophage cell number ( J:163407 )
• abnormal Mac-2-positive macrophages in the lung
abnormal macrophage physiology ( J:163407 )
• bone marrow-derived macrophages at 10-12 weeks of age stimulated with M-CSF and GM-CSF, show an increased proliferative response




Genotype
MGI:3574538
cx4
Allelic
Composition		 Dok1tm1Yyam/Dok1tm1Yyam
Dok2tm1Yyam/Dok2tm1Yyam
Tg(Tec-BCR/ABL1)5Hhi/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok1tm1Yyam mutation (0 available); any Dok1 mutation (19 available)
Dok2tm1Yyam mutation (0 available); any Dok2 mutation (16 available)
Tg(Tec-BCR/ABL1)5Hhi mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:95335 )
• mutants begin to die at 4-5 months of age with few surviving beyond 6-9 months of age unlike mice hemizygous for Tg(BCR/ABL1)5Hhi which survive until 1 year of age

neoplasm
increased leukemia incidence ( J:95335 )
• severe blastic transformation is seen at 4-5 months of age with tumor cells composed of double positive immature T lymphoblasts

immune system
enlarged thymus ( J:95335 )
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age
enlarged lymph nodes ( J:95335 )
• enlarged lymph node with massive infiltration of lymphoblasts seen at 4-5 months of age

hematopoietic system
enlarged thymus ( J:95335 )
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

endocrine/exocrine glands
enlarged thymus ( J:95335 )
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
chronic myeloid leukemia DOID:8552 OMIM:608232
 J:95335




Genotype
MGI:3574539
cx5
Allelic
Composition		 Dok2tm1Yyam/Dok2tm1Yyam
Tg(Tec-BCR/ABL1)5Hhi/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dok2tm1Yyam mutation (0 available); any Dok2 mutation (16 available)
Tg(Tec-BCR/ABL1)5Hhi mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:95335 )
• mutants begin to die at 4-5 months of age with few surviving beyond 6-9 months of age unlike mice hemizygous for Tg(BCR/ABL1)5Hhi which survive until 1 year of age

neoplasm
increased leukemia incidence ( J:95335 )
• severe blastic transformation is seen at 4-5 months of age with tumor cells composed of double positive immature T lymphoblasts

immune system
enlarged thymus ( J:95335 )
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age
enlarged lymph nodes ( J:95335 )
• enlarged lymph node with massive infiltration of lymphoblasts seen at 4-5 months of age

hematopoietic system
enlarged thymus ( J:95335 )
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

endocrine/exocrine glands
enlarged thymus ( J:95335 )
• enlarged thymus with massive infiltration of lymphoblasts seen at 4-5 months of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
chronic myeloid leukemia DOID:8552 OMIM:608232
 J:95335




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory