Phenotypes associated with this allele

• Allele Symbol: Jak3^tm1Flv
• Allele Name: targeted mutation 1, Richard A Flavell
• Allele ID: MGI:3527456
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jak3^tm1Flv/Jak3^tm1Flv	involves: 129S1/Sv	MGI:3527488

Genotype
MGI:3527488

hm1

• Allelic Composition: Jak3^tm1Flv/Jak3^tm1Flv
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal T cell proliferation ( J:95794 )

• T cells fail to proliferate in response to either anti-CD4 or ConA stimulation

thymus hypoplasia ( J:95794 )

• the total cell number in the thymus is 20-5--fold less than in wild-type mice

enlarged spleen ( J:95794 )

• some homozygotes have enlarged spleens

arrested B cell differentiation ( J:95794 )

• mutant B cells fail to progress to the B220+ stage

increased CD4-positive, alpha-beta T cell number ( J:95794 )

• in homozygotes with enlarged spleens more CD4+ cells are found in the spleen and lymph nodes than exit the thymus

decreased CD8-positive, alpha-beta T cell number ( J:95794 )

• the number of CD8+ T cells in the lymph nodes and spleen is decreased

immune system

abnormal T cell proliferation ( J:95794 )

• T cells fail to proliferate in response to either anti-CD4 or ConA stimulation

thymus hypoplasia ( J:95794 )

• the total cell number in the thymus is 20-5--fold less than in wild-type mice

enlarged spleen ( J:95794 )

• some homozygotes have enlarged spleens

arrested B cell differentiation ( J:95794 )

• mutant B cells fail to progress to the B220+ stage

increased CD4-positive, alpha-beta T cell number ( J:95794 )

• in homozygotes with enlarged spleens more CD4+ cells are found in the spleen and lymph nodes than exit the thymus

decreased CD8-positive, alpha-beta T cell number ( J:95794 )

• the number of CD8+ T cells in the lymph nodes and spleen is decreased

small lymph nodes ( J:95794 )

• the mesenteric lymph nodes are to 1/3 the size of wild-type

endocrine/exocrine glands

thymus hypoplasia ( J:95794 )

• the total cell number in the thymus is 20-5--fold less than in wild-type mice

growth/size/body

enlarged spleen ( J:95794 )

• some homozygotes have enlarged spleens

cellular

abnormal T cell proliferation ( J:95794 )

• T cells fail to proliferate in response to either anti-CD4 or ConA stimulation