Phenotypes associated with this allele

• Allele Symbol: Cpe^tm1Yplo
• Allele Name: targeted mutation 1, Y Peng Loh
• Allele ID: MGI:3527901
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cpe^tm1Yplo/Cpe^tm1Yplo	involves: 129S1/Sv * C57BL/6	MGI:3528141

Genotype
MGI:3528141

hm1

• Allelic Composition: Cpe^tm1Yplo/Cpe^tm1Yplo
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:95741 )

• in 45-52 week old male and female homozygotes body fat content is 39.7% and 54.1% of body weight, respectively, compared to 18.4% and 20.8% for male and female wild-type mice, respectively

behavior/neurological

polyphagia ( J:95741 )

• at 12 weeks female homozygotes and at 30 weeks male and female homozygotes eat more than wild-type littermates

abnormal motor capabilities/coordination/movement ( J:95741 )

• homozygotes are impaired in almost every test of motor performance

lethargy ( J:95741 )

hyporesponsive to tactile stimuli ( J:95741 )

tremors ( J:95741 )

• several homozygotes display mild tremors

abnormal motor coordination/balance ( J:95741 )

• homozygotes are impaired in almost every test of coordination

abnormal placing response ( J:95741 )

• visual placing response is impaired

abnormal physical strength ( J:95741 )

• homozygotes are impaired in almost every test of strength

decreased grip strength ( J:95741 )

• grip strength is significantly impaired

abnormal gait ( J:95741 )

decreased vertical activity ( J:95741 )

decreased locomotor activity ( J:95741 )

• during the light phase male and female homozygotes are less active than their wild-type littermates at 12 weeks of age, however during the dark phase activity levels are similar

growth/size/body

obese ( J:95741 )

• by 8 weeks of age homozygotes weigh more than wild-type mice and by 40 weeks of age mutants weigh 2-3 times more than wild-type mice

increased body length ( J:95741 )

• 30 week old male homozygotes are significantly longer than wild-type males

homeostasis/metabolism

increased circulating leptin level ( J:95741 )

• in 40 -62 week old homozygotes plasma leptin is increased about 4-fold compared to wild-type mice

abnormal energy expenditure ( J:95741 )

• energy expenditure is decreased in homozygous mice compared to wild-type littermates

increased respiratory quotient ( J:95741 )

• respiratory quotient (CO₂/O₂) is increased in homozygous mice compared to wild-type littermates

abnormal glucose homeostasis ( J:95741 )

increased circulating glucose level ( J:95741 )

• in homozygous male plasma glucose levels were increased between 17 and 26 weeks of age and in homozygous females plasma glucose levels were elevated from 14 weeks of age on by at least 2.5-fold compared to wild-type mice

increased circulating insulin level ( J:95741 )

• fasting plasma insulin levels, mainly in the form of proinsulin, are increased 50- to 100-fold starting at 14-15 weeks of age

impaired glucose tolerance ( J:95741 )

• glucose tolerance is impaired at 12 and 30 weeks of age in both female and male homozygotes, however the plasma glucose levels after challenge are higher in homozygous females than in males

insulin resistance ( J:95741 )

• the reduction in plasma glucose levels after insulin injection is reduced in males and females

• insulin-induced glucose transport activity in epididymal adipose cells is reduced by about 50% in cells from male homozygotes and almost totally absent in cells from female homozygotes

muscle

abnormal muscle physiology ( J:95741 )

• at 15 weeks of age reduced abdominal muscle tone is seen

reproductive system

reduced fertility ( J:95741 )

• after pairing of homozygous males and females only 5% of females showed evidence of pregnancy compared to 89% of wild-type females after pairings of wild-type mice

nervous system

abnormal hypothalamus secretion ( J:95741 )

• mature gonadotropin releasing hormone levels are reduced about 75% in homozygous males and 50% in homozygous females compared to wild-type mice

• the levels of immature gonadotropin releasing hormone were similar in males and increased 2.2-fold in homozygous females compared to wild-type mice