Analysis Tools
adipose tissue
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• total body fat of males fed a standard chow diet was decreased by ~45% at the age of 16 weeks
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behavior/neurological
polyphagia
(
J:95740
)
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• increased daily food intake of normal chow but not the high-fat chow, with males ingesting 8.3% more calories than wild-type over a 24 hour period
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• increased locomotor activity during the dark but not light phase in 8 week old males
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cardiovascular system
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• increased heart rate during both dark and light phases in 8 week old males caused by increased sympathetic and decreased parasympathetic activity
• under fasting conditions, homozygotes showed a higher heart rate and maintained it for longer than wild-type before initiation of transient drops in heart rate
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growth/size/body
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• males gained less body weight on a regular chow diet and by 14 weeks of age were 10% lighter than wild-type
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• homozygous males fed a high fat diet were ~20% lighter than wild-type on the same diet at 14 weeks of age and females showed a similar resistance to diet-induced obesity
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homeostasis/metabolism
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• increased body temperature during the dark phase but not light phase in 8 week old males
• under fasting conditions, homozygotes had a small elevation in body temperature and maintained temperature for longer than wild-type before the initiation of transient drops in temperature
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• significantly increased caloric expenditure per kilogram body mass
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• homozygous males fed a high fat diet were ~20% lighter than wild-type on the same diet at 14 weeks of age and females showed a similar resistance to diet-induced obesity
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