Phenotypes associated with this allele

• Allele Symbol: Ren1^tm3Gom
• Allele Name: targeted mutation 3, R Ariel Gomez
• Allele ID: MGI:3527932
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ren1^tm3Gom/Ren1^tm3Gom	129S6/SvEvTac-Ren1^tm3Gom	MGI:3528009
ht2	Ren1^tm3Gom/Ren1^+	129S6/SvEvTac-Ren1^tm3Gom	MGI:3528017

Genotype
MGI:3528009

hm1

• Allelic Composition: Ren1^tm3Gom/Ren1^tm3Gom
• Genetic Background: 129S6/SvEvTac-Ren1^tm3Gom

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased systemic arterial blood pressure ( J:95786 )

• blood pressure is significantly reduced in homozygous females but not in males

homeostasis/metabolism

increased blood urea nitrogen level ( J:95786 )

• homozygous males have significantly elevated BUN however in homozygous females BUN is slightly but not significantly elevated

increased circulating potassium level ( J:95786 )

• potassium levels are increased in both homozygous males and females

decreased circulating renin level ( J:95786 )

• kidney renin concentrations are reduced to 10-20% of wild-type and plasma renin concentrations reduced to 1% and 30% of wild-type in homozygous females and males, respectively

renal/urinary system

abnormal kidney cortex morphology ( J:95786 )

• undifferentiated cells are seen adjacent to the tubule in the outer cortex

abnormal juxtaglomerular cell morphology ( J:95786 )

• only rare, small and thin, renin positive cells are seen in homozygotes and the number of renin positive cells does not increase after treatment with the ACE inhibitor captopril unlike in wild-type and heterozygous mice

abnormal renal glomerulus morphology ( J:95786 )

• about 25% of glomeruli show damage with 8.3% enlarged and hypercellular and 16% shrunken

• alpha-SMA positive cells are seen within the glomeruli similar to immature kidneys, however the thickness of the afferent arterioles and interlobular arteries is similar to wild-type

renal glomerulus fibrosis ( J:95786 )

• increased collagen deposition is seen in the glomeruli

renal glomerulus hypertrophy ( J:95786 )

• 8.3% of glomeruli are enlarged and hypercellular

renal interstitial fibrosis ( J:95786 )

• increased collagen deposition is seen in some interstitial areas

abnormal kidney medulla morphology ( J:95786 )

• in severely affected kidneys the border between the inner and outer medullary bands is absent

small kidney ( J:95786 )

• kidneys are smaller than wild-type

decreased kidney weight ( J:95786 )

• kidneys weigh significantly less compared to wild-type

kidney atrophy ( J:95786 )

• in severe cases kidneys appear shrunken

renal glomerulus atrophy ( J:95786 )

• 16% of glomeruli appear shrunken; mainly located in areas containing abnormal tubules

kidney cortex atrophy ( J:95786 )

• in severely affected kidneys the cortex is thinner than normal

renal tubule atrophy ( J:95786 )

• tubular atrophy is seen in areas of the cortex

proximal convoluted tubule brush border loss ( J:95786 )

• reduced brush borders are seen on some proximal tubules

dilated renal tubule ( J:95786 )

• tubular dilation is seen in areas of the cortex

granular kidney ( J:95786 )

• in severe cases kidneys appear shrunken without the normal shiny appearance and with a granular aspect and white fat patches

Genotype
MGI:3528017

ht2

• Allelic Composition: Ren1^tm3Gom/Ren1⁺
• Genetic Background: 129S6/SvEvTac-Ren1^tm3Gom

homeostasis/metabolism

decreased circulating renin level ( J:95786 )

• in heterozygous females kidney and plasma renin concentrations are reduced to 60% and 10% of wild-type, respectively no significant difference is found between heterozygous and wild-type males

renal/urinary system

abnormal juxtaglomerular cell morphology ( J:95786 )

• fewer renin positive cells are seen in heterozygotes