Phenotypes associated with this allele

• Allele Symbol: Aph1a^tm1Pcw
• Allele Name: targeted mutation 1, Philip C Wong
• Allele ID: MGI:3527942
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aph1a^tm1Pcw/Aph1a^tm1Pcw	involves: 129X1/SvJ * C57BL/6	MGI:3527992

Genotype
MGI:3527992

hm1

• Allelic Composition: Aph1a^tm1Pcw/Aph1a^tm1Pcw
• Genetic Background: involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:95769 )

• no homozygous embryos recovered after E11

cardiovascular system

abnormal vitelline vasculature morphology ( J:95769 )

• homozygous E9.5 embryos exhibit abnormal vascular morphogenesis of the yolk sac

abnormal heart development ( J:95769 )

• underdeveloped heart chambers

distended pericardium ( J:95769 )

embryo

abnormal vitelline vasculature morphology ( J:95769 )

• homozygous E9.5 embryos exhibit abnormal vascular morphogenesis of the yolk sac

small first pharyngeal arch ( J:95769 )

• underdeveloped first branchial arch

embryonic growth arrest ( J:95769 )

• development of homozygotes was retarded by E9.5, growth was arrested by E10.5, and no heartbeats were detected in the few E11 embryos that were recovered

kinked neural tube ( J:95769 )

• E8.5 embryos had kinks in the caudal part of the neural tube

abnormal somite development ( J:95769 )

• abnormal patterning of somites in E8.5 embryos

nervous system

kinked neural tube ( J:95769 )

• E8.5 embryos had kinks in the caudal part of the neural tube

craniofacial

small first pharyngeal arch ( J:95769 )

• underdeveloped first branchial arch