All Phenotypes Tgm2<tm1.1Rmgr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tgm2^tm1.1Rmgr
targeted mutation 1.1, Robert M Graham
MGI:3527996

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tgm2^tm1.1Rmgr/Tgm2^tm1.1Rmgr	129(B6)-Tgm2^tm1.1Rmgr	MGI:5521591
hm2	Tgm2^tm1.1Rmgr/Tgm2^tm1.1Rmgr	B6.129S1-Tgm2^tm1.1Rmgr	MGI:5521588
hm3	Tgm2^tm1.1Rmgr/Tgm2^tm1.1Rmgr	involves: 129S1/SvImJ * C57BL/6	MGI:3528230
cx4	Tgm2^tm1.1Rmgr/Tgm2^tm1.1Rmgr Tg(HDexon1)62Gpb/0	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:3528066
cx5	Tgm2^tm1.1Rmgr/Tgm2⁺ Tg(HDexon1)62Gpb/0	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:3528067

Allelic Composition	Tgm2^tm1.1Rmgr/Tgm2^tm1.1Rmgr
Genetic Background	129(B6)-Tgm2^tm1.1Rmgr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgm2^tm1.1Rmgr mutation (2 available); any Tgm2 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:200838 )

N	• Background Sensitivity: unlike mice on a congenic C57BL/6 background, mice on a congenic 129S1/Sv background exhibit normal weight gain when fed a high fat diet

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:200838 )

N	• whether fed standard chow or a high fat diet, mice exhibit normal glucose tolerance, insulin sensitivity and glucose stimulated insulin secretion

Allelic Composition	Tgm2^tm1.1Rmgr/Tgm2^tm1.1Rmgr
Genetic Background	B6.129S1-Tgm2^tm1.1Rmgr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgm2^tm1.1Rmgr mutation (2 available); any Tgm2 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:200838 )

• Background Sensitivity: mice on a a congenic C57BL/6 background exhibit increased body weight when fed a high fat diet unlike mice on a congenic 129S1/Sv background

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:200838 )

N	• whether fed standard chow or a high fat diet, mice exhibit normal glucose tolerance, insulin sensitivity and glucose stimulated insulin secretion

Allelic Composition	Tgm2^tm1.1Rmgr/Tgm2^tm1.1Rmgr
Genetic Background	involves: 129S1/SvImJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgm2^tm1.1Rmgr mutation (2 available); any Tgm2 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell adhesion ( J:95130 )

• fewer homozygous fibroblasts (20% versus 79% of wild-type) adhered to poly-L-coated or fibronectin coated slides

immune system

abnormal T cell physiology ( J:95130 )

• 24 hours after induction of apoptosis by dexamethasone treatment, homozygotes had smaller thymuses due to decreased viability of thymocytes and increased clearance of dead cells compared to controls, however mutants are viable, normal in size and weight, have normal separation of digits and open eyelids and no difference in thymocyte numbers, indicating that developmental apoptosis was not impaired

hematopoietic system

abnormal T cell physiology ( J:95130 )

Allelic Composition	Tgm2^tm1.1Rmgr/Tgm2^tm1.1Rmgr Tg(HDexon1)62Gpb/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(HDexon1)62Gpb mutation (22 available)
Tgm2^tm1.1Rmgr mutation (2 available); any Tgm2 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

extended life span ( J:95452 )

• mean lifespan of mutants was increased by 19.7% compared Tg(HDexon1)62Gpb transgenic mice

behavior/neurological

impaired coordination ( J:95452 )

• mutants showed a delayed onset of motor dysfunction compared to Tg(HDexon1)62Gpb transgenic mice at 9, 10, and 11 weeks of age

nervous system

abnormal striatum morphology ( J:95452 )

• 10 week-old mutants had 30-35% more huntingtin protein aggregates within the cerebral cortex and striatum than Tg(HDexon1)62Gpb transgenic mice

abnormal cerebral cortex morphology ( J:95452 )

• 10 week-old mutants had 30-35% more huntingtin protein aggregates within the cerebral cortex and striatum than Tg(HDexon1)62Gpb transgenic mice

Allelic Composition	Tgm2^tm1.1Rmgr/Tgm2⁺ Tg(HDexon1)62Gpb/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(HDexon1)62Gpb mutation (22 available)
Tgm2^tm1.1Rmgr mutation (2 available); any Tgm2 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal striatum morphology ( J:95452 )

• mutants had more huntingtin protein aggregates within the cerebral cortex and striatum but no difference in the onset of motor dysfunction and the mean lifespan compared to Tg(HDexon1)62Gpb transgenic mice

abnormal cerebral cortex morphology ( J:95452 )

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