Phenotypes associated with this allele

• Allele Symbol: Plxnd1^tm1Ddg
• Allele Name: targeted mutation 1, David D Ginty
• Allele ID: MGI:3527997
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plxnd1^tm1Ddg/Plxnd1^tm1Ddg	involves: 129S/SvEv * C57BL/6J	MGI:3528188
cn2	Plxnd1^tm1Ddg/Plxnd1^tm1.1Tmj H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA/J	MGI:3848832
cn3	Plxnd1^tm1Ddg/Plxnd1^tm1.1Tmj Tg(CAG-cre/Esr1*)1Egwa/0	involves: 129S/SvEv * C57BL/6 * DBA/2	MGI:5052373
cn4	Plxnd1^tm1Ddg/Plxnd1^tm1.1Tmj H2az2^Tg(Wnt1-cre)11Rth/H2az2^+	involves: 129S/SvEv * C57BL/6J * CBA/J	MGI:5550533

Genotype
MGI:3528188

hm1

• Allelic Composition: Plxnd1^tm1Ddg/Plxnd1^tm1Ddg
• Genetic Background: involves: 129S/SvEv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal intersomitic vessel morphology ( J:95697 )

• at E10.5 and E11.5, the intersomitic vessels are disorganized and extend ectopically throughout the somite

Genotype
MGI:3848832

cn2

• Allelic Composition: Plxnd1^tm1Ddg/Plxnd1^tm1.1Tmj; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA/J

nervous system

abnormal motor neuron morphology ( J:149553 )

• mice exhibit a 3-fold increase in the number of proprioceptive synaptic contacts with identified cutaneous maximus motor neurons compared to in wild-type mice

abnormal motor neuron innervation pattern ( J:149553 )

• 43% of cutaneous motor neurons receive monosynaptic input after stimulation of cutaneous maximus afferents unlike wild-type motor neurons

• however, monosynaptic specificity from the tricep is normal

behavior/neurological

behavior/neurological phenotype ( J:149553 )

N • mice exhibit no behavior deficits

Genotype
MGI:5052373

cn3

• Allelic Composition: Plxnd1^tm1Ddg/Plxnd1^tm1.1Tmj; Tg(CAG-cre/Esr1*)1Egwa/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

Increase in extraretinal vascular outgrowth in ischemic Plxnd1^tm1.1Tmj/Plxnd1^tm1Ddg Tg(CAG-cre/Esr1*)1Egwa/0 retinas

vision/eye

abnormal induced retina neovascularization ( J:173943 )

• tamoxifen-treated mice exhibit increased extraretinal vascular outgrowth in ischemic retinas compared with control mice

cardiovascular system

abnormal induced retina neovascularization ( J:173943 )

• tamoxifen-treated mice exhibit increased extraretinal vascular outgrowth in ischemic retinas compared with control mice

Genotype
MGI:5550533

cn4

• Allelic Composition: Plxnd1^tm1Ddg/Plxnd1^tm1.1Tmj; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6J * CBA/J

nervous system

nervous system phenotype ( J:205528 )

N • the patterns of hamstring knee flexor muscle and gluteus homonymous monosynaptic sensory-motor connections are similar to controls

abnormal excitatory postsynaptic potential ( J:205528 )

• a large amplitude of monosynaptic EPSP is seen in 45% of gluteus motor neurons unlike in controls