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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Plxnd1tm1Ddg
targeted mutation 1, David D Ginty
MGI:3527997
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Plxnd1tm1Ddg/Plxnd1tm1Ddg involves: 129S/SvEv * C57BL/6J MGI:3528188
cn2
 		Plxnd1tm1Ddg/Plxnd1tm1.1Tmj
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA/J MGI:3848832
cn3
 		Plxnd1tm1Ddg/Plxnd1tm1.1Tmj
Tg(CAG-cre/Esr1*)1Egwa/0 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:5052373
cn4
 		Plxnd1tm1Ddg/Plxnd1tm1.1Tmj
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S/SvEv * C57BL/6J * CBA/J MGI:5550533


Genotype
MGI:3528188
hm1
Allelic
Composition		 Plxnd1tm1Ddg/Plxnd1tm1Ddg
Genetic
Background		 involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnd1tm1Ddg mutation (0 available); any Plxnd1 mutation (86 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal intersomitic vessel morphology ( J:95697 )
• at E10.5 and E11.5, the intersomitic vessels are disorganized and extend ectopically throughout the somite




Genotype
MGI:3848832
cn2
Allelic
Composition		 Plxnd1tm1Ddg/Plxnd1tm1.1Tmj
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Plxnd1tm1.1Tmj mutation (1 available); any Plxnd1 mutation (86 available)
Plxnd1tm1Ddg mutation (0 available); any Plxnd1 mutation (86 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal motor neuron morphology ( J:149553 )
• mice exhibit a 3-fold increase in the number of proprioceptive synaptic contacts with identified cutaneous maximus motor neurons compared to in wild-type mice
abnormal motor neuron innervation pattern ( J:149553 )
• 43% of cutaneous motor neurons receive monosynaptic input after stimulation of cutaneous maximus afferents unlike wild-type motor neurons
• however, monosynaptic specificity from the tricep is normal

behavior/neurological
behavior/neurological phenotype ( J:149553 )
N
• mice exhibit no behavior deficits




Genotype
MGI:5052373
cn3
Allelic
Composition		 Plxnd1tm1Ddg/Plxnd1tm1.1Tmj
Tg(CAG-cre/Esr1*)1Egwa/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxnd1tm1.1Tmj mutation (1 available); any Plxnd1 mutation (86 available)
Plxnd1tm1Ddg mutation (0 available); any Plxnd1 mutation (86 available)
Tg(CAG-cre/Esr1*)1Egwa mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Increase in extraretinal vascular outgrowth in ischemic Plxnd1tm1.1Tmj/Plxnd1tm1Ddg Tg(CAG-cre/Esr1*)1Egwa/0 retinas

vision/eye
abnormal induced retina neovascularization ( J:173943 )
• tamoxifen-treated mice exhibit increased extraretinal vascular outgrowth in ischemic retinas compared with control mice

cardiovascular system
abnormal induced retina neovascularization ( J:173943 )
• tamoxifen-treated mice exhibit increased extraretinal vascular outgrowth in ischemic retinas compared with control mice




Genotype
MGI:5550533
cn4
Allelic
Composition		 Plxnd1tm1Ddg/Plxnd1tm1.1Tmj
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S/SvEv * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Plxnd1tm1.1Tmj mutation (1 available); any Plxnd1 mutation (86 available)
Plxnd1tm1Ddg mutation (0 available); any Plxnd1 mutation (86 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:205528 )
N
• the patterns of hamstring knee flexor muscle and gluteus homonymous monosynaptic sensory-motor connections are similar to controls
abnormal excitatory postsynaptic potential ( J:205528 )
• a large amplitude of monosynaptic EPSP is seen in 45% of gluteus motor neurons unlike in controls




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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory