Phenotypes associated with this allele

• Allele Symbol: Rassf1^tm1Gpp
• Allele Name: targeted mutation 1, Gerd P Pfeifer
• Allele ID: MGI:3528065
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rassf1^tm1Gpp/Rassf1^tm1Gpp	involves: 129S1/SvImJ	MGI:5784898
hm2	Rassf1^tm1Gpp/Rassf1^tm1Gpp	involves: 129S1/SvImJ * C57BL/6	MGI:3528191
ht3	Rassf1^tm1Gpp/Rassf1^+	involves: 129S1/SvImJ * C57BL/6	MGI:3528192
cx4	Rassf1^tm1Gpp/Rassf1^tm1Gpp Sav1^tm1.1Gpp/Sav1^+	involves: 129S1/Sv * 129S1/SvImJ	MGI:5784899

Genotype
MGI:5784898

hm1

• Allelic Composition: Rassf1^tm1Gpp/Rassf1^tm1Gpp
• Genetic Background: involves: 129S1/SvImJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

increased liver tumor incidence ( J:231761 )

• 42% of mice develop liver tumors

• liver tumors vary from small, solitary nodules to large, multinodular masses taking up entire lobes of the liver

increased hepatocellular carcinoma incidence ( J:231761 )

• 8.9% of mice exhibit hepatocellular carcinoma

• 2.2% of mice exhibit mixed hepatocellular carcinoma

increased liver adenoma incidence ( J:231761 )

• 31.1% of mice exhibit hepatocellular adenoma

• 4.4% of mice exhibit mixed hepatocellular adenoma

abnormal oval cell morphology ( J:231761 )

• occasionally, livers show signs of oval cell hyperplasia

neoplasm

increased liver tumor incidence ( J:231761 )

• 42% of mice develop liver tumors

• liver tumors vary from small, solitary nodules to large, multinodular masses taking up entire lobes of the liver

increased hepatocellular carcinoma incidence ( J:231761 )

• 8.9% of mice exhibit hepatocellular carcinoma

• 2.2% of mice exhibit mixed hepatocellular carcinoma

increased liver adenoma incidence ( J:231761 )

• 31.1% of mice exhibit hepatocellular adenoma

• 4.4% of mice exhibit mixed hepatocellular adenoma

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:231761 )

N • mice do not exhibit bile duct hyperplasia

Genotype
MGI:3528191

hm2

• Allelic Composition: Rassf1^tm1Gpp/Rassf1^tm1Gpp
• Genetic Background: involves: 129S1/SvImJ * C57BL/6

neoplasm

increased incidence of tumors by chemical induction ( J:95683 )

• benzo(a)pyrene induced significantly larger skin tumors and about 50% of these tumors were squamous cell carcinomas which are not seen in wild-type mice

• urethane exposure resulted in increased tumor load and multiplicity in homozygotes compared to wild-type mice

increased lung adenoma incidence ( J:95683 )

• 5 out of 41 homozygotes had lung adenomas consisting of circumscribed but nonencapsulated closely packed acini of cuboidal and low columnar epithelial cells and some had papillary formations or nuclear pleomorphisms

increased B cell derived lymphoma incidence ( J:95683 )

• 4 out of 41 homozygotes had high-grade B cell lymphomas

• individual cases of leukemia, breast adenocarcinoma, and rectal papilloma were also seen

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:95683 )

• benzo(a)pyrene induced significantly larger skin tumors and about 50% of these tumors were squamous cell carcinomas which are not seen in wild-type mice

• urethane exposure resulted in increased tumor load and multiplicity in homozygotes compared to wild-type mice

respiratory system

increased lung adenoma incidence ( J:95683 )

• 5 out of 41 homozygotes had lung adenomas consisting of circumscribed but nonencapsulated closely packed acini of cuboidal and low columnar epithelial cells and some had papillary formations or nuclear pleomorphisms

Genotype
MGI:3528192

ht3

• Allelic Composition: Rassf1^tm1Gpp/Rassf1⁺
• Genetic Background: involves: 129S1/SvImJ * C57BL/6

neoplasm

increased incidence of tumors by chemical induction ( J:95683 )

• benzo(a)pyrene induced significantly larger skin tumors and about 50% of these tumors were squamous cell carcinomas which are not seen in wild-type mice

• urethane exposure resulted in increased tumor load and multiplicity in heterozygotes compared to wild-type mice

increased lung adenoma incidence ( J:95683 )

• 4 out of 35 heterozygotes had lung adenomas

• individual cases of high-grade B cell lymphoma and sarcoma were also seen

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:95683 )

• benzo(a)pyrene induced significantly larger skin tumors and about 50% of these tumors were squamous cell carcinomas which are not seen in wild-type mice

• urethane exposure resulted in increased tumor load and multiplicity in heterozygotes compared to wild-type mice

respiratory system

increased lung adenoma incidence ( J:95683 )

• 4 out of 35 heterozygotes had lung adenomas

• individual cases of high-grade B cell lymphoma and sarcoma were also seen

Genotype
MGI:5784899

cx4

• Allelic Composition: Rassf1^tm1Gpp/Rassf1^tm1Gpp; Sav1^tm1.1Gpp/Sav1⁺
• Genetic Background: involves: 129S1/Sv * 129S1/SvImJ

endocrine/exocrine glands

bile duct hyperplasia ( J:231761 )

• about 15-20% of mice show bile duct hyperplasia compared to about 7% of wild-type mice

liver/biliary system

bile duct hyperplasia ( J:231761 )

• about 15-20% of mice show bile duct hyperplasia compared to about 7% of wild-type mice

increased liver tumor incidence ( J:231761 )

• 90% of mice develop liver tumors

increased hepatoblastoma incidence ( J:231761 )

• 2.6% of mice exhibit hepatoblastoma

increased hepatocellular carcinoma incidence ( J:231761 )

• 77% of mice exhibit hepatocellular carcinoma

• 23.1% of mice exhibit mixed hepatocellular carcinoma

increased liver adenoma incidence ( J:231761 )

• 79.5% of mice exhibit hepatocellular adenoma

• 38.5% of mice exhibit mixed hepatocellular adenoma

abnormal oval cell morphology ( J:231761 )

• more than 50% of mice show signs of oval cell hyperplasia

neoplasm

increased liver tumor incidence ( J:231761 )

• 90% of mice develop liver tumors

increased hepatoblastoma incidence ( J:231761 )

• 2.6% of mice exhibit hepatoblastoma

increased hepatocellular carcinoma incidence ( J:231761 )

• 77% of mice exhibit hepatocellular carcinoma

• 23.1% of mice exhibit mixed hepatocellular carcinoma

increased liver adenoma incidence ( J:231761 )

• 79.5% of mice exhibit hepatocellular adenoma

• 38.5% of mice exhibit mixed hepatocellular adenoma