Phenotypes associated with this allele

• Allele Symbol: Drd5^tm1Sib
• Allele Name: targeted mutation 1, David R Sibley
• Allele ID: MGI:3528074
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Drd5^tm1Sib/Drd5^tm1Sib	B6.129S4-Drd5^tm1Sib	MGI:3528685
hm2	Drd5^tm1Sib/Drd5^tm1Sib	involves: 129S4/SvJae * C57BL/6	MGI:3528669

Genotype
MGI:3528685

hm1

• Allelic Composition: Drd5^tm1Sib/Drd5^tm1Sib
• Genetic Background: B6.129S4-Drd5^tm1Sib

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased systemic arterial blood pressure ( J:95570 )

• significantly elevated mean arterial blood pressure under pentobarbital anesthesia

increased systemic arterial diastolic blood pressure ( J:95570 )

• significantly elevated diastolic blood pressure under pentobarbital anesthesia

increased systemic arterial systolic blood pressure ( J:95570 )

• significantly elevated systolic blood pressure under pentobarbital anesthesia

renal/urinary system

abnormal kidney physiology ( J:95570 )

• increased phospholipase D activity in the kidney

Genotype
MGI:3528669

hm2

• Allelic Composition: Drd5^tm1Sib/Drd5^tm1Sib
• Genetic Background: involves: 129S4/SvJae * C57BL/6

cardiovascular system

increased heart weight ( J:95908 )

• adults, but not 2 month old mutants, exhibited elevated heart weight

increased systemic arterial blood pressure ( J:95570 , J:95908 )

• significantly elevated mean arterial blood pressure under pentobarbital anesthesia (J:95570)

• significantly elevated mean blood pressure (127 vs 103 mmHg in wildtype) by 3 months of age (J:95908)

hypertension ( J:95908 )

• hypertension caused by increased sympathetic tone

increased systemic arterial diastolic blood pressure ( J:95570 , J:95908 )

• significantly elevated diastolic blood pressure under pentobarbital anesthesia (J:95570)

• significantly elevated diastolic blood pressure (115 vs 93 mmHg in wildtype) (J:95908)

increased systemic arterial systolic blood pressure ( J:95570 , J:95908 )

• significantly elevated systolic blood pressure under pentobarbital anesthesia (J:95570)

• significantly elevated systolic blood pressure (154 vs 119 mmHg in wildtype) (J:95908)

endocrine/exocrine glands

abnormal adrenal gland physiology ( J:95908 )

• although no difference in the absolute levels of norepinephrine or epinephrine were observed, there was a significant elevation in the epinephrine/norepinephrine ratio in adrenal glands

renal/urinary system

abnormal kidney physiology ( J:95570 )

• increased phospholipase D activity in the kidney

nervous system

abnormal sympathetic nervous system physiology ( J:95908 )

• greater reduction in mean arterial pressure after adrenalectomy or with alpha-adrenergic blockade, suggesting that hypertension was caused by increased sympathetic activity

• antagonists of the non-NMDA glutamatergic receptor, oxytocin, or V1 vasopressin reduced blood pressure in mutants but not in wildtype, indicating an increased sympathetic outflow in mutants

growth/size/body

increased heart weight ( J:95908 )

• adults, but not 2 month old mutants, exhibited elevated heart weight