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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Lck-Tal1)4709Led
transgene insertion 4709, Philip Leder
MGI:3528080
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Lck-Tal1)4709Led/0 FVB/N-Tg(Lck-Tal1)4709Led MGI:3849439


Genotype
MGI:3849439
tg1
Allelic
Composition
Tg(Lck-Tal1)4709Led/0
Genetic
Background
FVB/N-Tg(Lck-Tal1)4709Led
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival is 350 days

neoplasm
• mice develop clonal T cell lymphoblastic leukemia/lymphoma
• mice exhibit lymphoblastic infiltrates in the thymus, para-sternal muscle, pericardium, spleen, liver, and kidneys
• mice develop clonal T cell lymphoblastic leukemia/lymphoma

immune system
• mice develop thymic masses composed of lymphoblastic cells with prominent nucleoli and scant cytoplasm unlike wild-type mice
• mice develop clonal T cell lymphoblastic leukemia/lymphoma

respiratory system
• in mice that develop tumors

liver/biliary system

growth/size/body
• in mice that develop tumors

hematopoietic system
• mice develop thymic masses composed of lymphoblastic cells with prominent nucleoli and scant cytoplasm unlike wild-type mice
• mice develop clonal T cell lymphoblastic leukemia/lymphoma

integument
• in mice that develop tumors

endocrine/exocrine glands
• mice develop thymic masses composed of lymphoblastic cells with prominent nucleoli and scant cytoplasm unlike wild-type mice
• mice develop clonal T cell lymphoblastic leukemia/lymphoma

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
lymphoid leukemia DOID:1037 J:36076





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory