mortality/aging
• median survival is 350 days
|
neoplasm
• mice develop clonal T cell lymphoblastic leukemia/lymphoma
|
• mice exhibit lymphoblastic infiltrates in the thymus, para-sternal muscle, pericardium, spleen, liver, and kidneys
• mice develop clonal T cell lymphoblastic leukemia/lymphoma
|
immune system
• mice develop thymic masses composed of lymphoblastic cells with prominent nucleoli and scant cytoplasm unlike wild-type mice
|
• mice develop clonal T cell lymphoblastic leukemia/lymphoma
|
respiratory system
• in mice that develop tumors
|
liver/biliary system
growth/size/body
weight loss
(
J:36076
)
• in mice that develop tumors
|
hematopoietic system
• mice develop thymic masses composed of lymphoblastic cells with prominent nucleoli and scant cytoplasm unlike wild-type mice
|
• mice develop clonal T cell lymphoblastic leukemia/lymphoma
|
integument
ruffled hair
(
J:36076
)
• in mice that develop tumors
|
endocrine/exocrine glands
• mice develop thymic masses composed of lymphoblastic cells with prominent nucleoli and scant cytoplasm unlike wild-type mice
|
• mice develop clonal T cell lymphoblastic leukemia/lymphoma
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
lymphoid leukemia | DOID:1037 | J:36076 |