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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Card11tm1Vmd
targeted mutation 1, Vishva M Dixit
MGI:3528226
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Card11tm1Vmd/Card11tm1Vmd involves: 129S6/SvEvTac * C57BL/6N MGI:3528445
ht2
 		Card11tm1Vmd/Card11+ involves: 129S6/SvEvTac * C57BL/6N MGI:3528448


Genotype
MGI:3528445
hm1
Allelic
Composition		 Card11tm1Vmd/Card11tm1Vmd
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card11tm1Vmd mutation (0 available); any Card11 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell proliferation ( J:95800 )
• antibody-stimulated T cells fail to grow and proliferate and fewer mutant T cells are viable following stimulation (14% compared to 35% of wild-type T cells)
• addition of exogenous IL-2 restores T cell proliferation
absent immature B cells ( J:95800 )
• no B220+ IgM+ CD5+ B cells are found in the peritoneum
decreased B cell proliferation ( J:95800 )
• mitogen-induced proliferation is impaired and addition of exogenous IL-2 does not restore proliferation
decreased IgA level ( J:95800 )
• levels of IgA are below detection in 7 out of 9 nave homozygotes
decreased IgG level ( J:95800 )
• levels of IgG2b and IgG3 isotypes are below detection and levels of IgG1 and IgG2a are reduced to 36-40% of wild-type
decreased IgM level ( J:95800 )
• levels of IgM are below detection

immune system
decreased T cell proliferation ( J:95800 )
• antibody-stimulated T cells fail to grow and proliferate and fewer mutant T cells are viable following stimulation (14% compared to 35% of wild-type T cells)
• addition of exogenous IL-2 restores T cell proliferation
absent immature B cells ( J:95800 )
• no B220+ IgM+ CD5+ B cells are found in the peritoneum
decreased B cell proliferation ( J:95800 )
• mitogen-induced proliferation is impaired and addition of exogenous IL-2 does not restore proliferation
decreased IgA level ( J:95800 )
• levels of IgA are below detection in 7 out of 9 nave homozygotes
decreased IgG level ( J:95800 )
• levels of IgG2b and IgG3 isotypes are below detection and levels of IgG1 and IgG2a are reduced to 36-40% of wild-type
decreased IgM level ( J:95800 )
• levels of IgM are below detection

cellular
decreased B cell proliferation ( J:95800 )
• mitogen-induced proliferation is impaired and addition of exogenous IL-2 does not restore proliferation
decreased T cell proliferation ( J:95800 )
• antibody-stimulated T cells fail to grow and proliferate and fewer mutant T cells are viable following stimulation (14% compared to 35% of wild-type T cells)
• addition of exogenous IL-2 restores T cell proliferation




Genotype
MGI:3528448
ht2
Allelic
Composition		 Card11tm1Vmd/Card11+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card11tm1Vmd mutation (0 available); any Card11 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B cell proliferation ( J:95800 )
• mitogen-induced proliferation is impaired and addition of exogenous IL-2 does not restore proliferation

hematopoietic system
decreased B cell proliferation ( J:95800 )
• mitogen-induced proliferation is impaired and addition of exogenous IL-2 does not restore proliferation

cellular
decreased B cell proliferation ( J:95800 )
• mitogen-induced proliferation is impaired and addition of exogenous IL-2 does not restore proliferation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory