Analysis Tools|
Allele Symbol Allele Name Allele ID |
Bag1tm1Msd targeted mutation 1, Michael Sendtner MGI:3528234 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• embryos die around E13.5
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• at E12.5 the liver is hypoplastic with increased levels of apoptosis compared to wild-type littermates
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• lung tumor initiation is reduced by half at 1, 2, and 4 months of age and lung tumor area is reduced by 75% at 4 months of age
• the number of apoptotic cells in the lung adenomas is increased in double mutants compared to littermates that are wild-type for Bag1
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• lung tumor initiation is reduced by half at 1, 2, and 4 months of age and lung tumor area is reduced by 75% at 4 months of age
• the number of apoptotic cells in the lung adenomas is increased in double mutants compared to littermates that are wild-type for Bag1
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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