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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Bag1tm1Msd
targeted mutation 1, Michael Sendtner
MGI:3528234
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Bag1tm1Msd/Bag1tm1Msd involves: C57BL/6 MGI:3529133
cx2
 		Bag1tm1Msd/Bag1+
Tg(SFTPC-RAF1-BxB)1Urr/0 		involves: C57BL/6 MGI:3529140


Genotype
MGI:3529133
hm1
Allelic
Composition		 Bag1tm1Msd/Bag1tm1Msd
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bag1tm1Msd mutation (0 available); any Bag1 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

liver/biliary system
liver hypoplasia ( J:95491 )
• at E12.5 the liver is hypoplastic with increased levels of apoptosis compared to wild-type littermates




Genotype
MGI:3529140
cx2
Allelic
Composition		 Bag1tm1Msd/Bag1+
Tg(SFTPC-RAF1-BxB)1Urr/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bag1tm1Msd mutation (0 available); any Bag1 mutation (20 available)
Tg(SFTPC-RAF1-BxB)1Urr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased lung tumor incidence ( J:95491 )
• lung tumor initiation is reduced by half at 1, 2, and 4 months of age and lung tumor area is reduced by 75% at 4 months of age
• the number of apoptotic cells in the lung adenomas is increased in double mutants compared to littermates that are wild-type for Bag1




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
07/05/2024
MGI 6.24 		The Jackson Laboratory