All Phenotypes En1<tm7(cre/ESR1)Alj> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

En1^{tm7(cre/ESR1)Alj}
targeted mutation 7, Alexandra L Joyner
MGI:3528251

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	En1^{tm7(cre/ESR1)Alj}/0 Fgf8^tm1.1Jyhl/Fgf8^tm1.3Mrt	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:4437222
cn2	En1^{tm7(cre/ESR1)Alj}/0 Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:4437223
cn3	En1^{tm7(cre/ESR1)Alj}/0 Fgf8^tm1.3Mrt/Fgf8^tm2.1Jyhl Gt(ROSA)26Sor^tm1Sor/0	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:4437229
cn4	En1^{tm7(cre/ESR1)Alj}/En1⁺ En2^tm2Alj/En2^tm2Alj Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺	involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster	MGI:3789333

Allelic Composition	En1^{tm7(cre/ESR1)Alj}/0 Fgf8^tm1.1Jyhl/Fgf8^tm1.3Mrt
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^{tm7(cre/ESR1)Alj} mutation (1 available); any En1 mutation (33 available)
Fgf8^tm1.1Jyhl mutation (0 available); any Fgf8 mutation (21 available)
Fgf8^tm1.3Mrt mutation (1 available); any Fgf8 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:156717 )

• die at birth

nervous system

abnormal neural tube morphology ( J:156717 )

• a significant increase in the number of dead cells in the mesencephalon and to a less extent in rhombomere of the neural tube of embryos at the 13-somite stage

abnormal rhombomere morphology ( J:156717 )

• a significant increase in the number of dead cells in rhombomere of the neural tube of embryos at the 13-somite stage

abnormal Raphe nucleus morphology ( J:156717 )

• a reduction of serotonergic neurons in raphe nuclei

abnormal midbrain morphology ( J:156717 )

• E18.5 revealed a nearly complete loss of the midbrain and the cerebellum

• a significant increase in the number of dead cells in the mesencephalon at the 13-somite stage

abnormal substantia nigra morphology ( J:156717 )

• depletion of dopaminergic neurons at E18.5

small cerebellum ( J:156717 )

• E18.5 revealed a nearly complete loss of the midbrain and the cerebellum

decreased dopaminergic neuron number ( J:156717 )

• at E18.5 in the substantia nigra and ventral tegmental area

abnormal serotonergic neuron morphology ( J:156717 )

• at E18.5 a reduction of serotonergic neurons in the raphe nucleus

embryo

abnormal neural tube morphology ( J:156717 )

• a significant increase in the number of dead cells in the mesencephalon and to a less extent in rhombomere of the neural tube of embryos at the 13-somite stage

abnormal rhombomere morphology ( J:156717 )

• a significant increase in the number of dead cells in rhombomere of the neural tube of embryos at the 13-somite stage

Allelic Composition	En1^{tm7(cre/ESR1)Alj}/0 Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^{tm7(cre/ESR1)Alj} mutation (1 available); any En1 mutation (33 available)
Fgf8^tm1.3Mrt mutation (1 available); any Fgf8 mutation (21 available)
Fgf8^tm1.4Mrt mutation (0 available); any Fgf8 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal Raphe nucleus morphology ( J:156717 )

• a reduction of serotonergic neurons in raphe nuclei

abnormal midbrain morphology ( J:156717 )

• E18.5 revealed a nearly complete loss of the midbrain and the cerebellum

abnormal substantia nigra morphology ( J:156717 )

• depletion of dopaminergic neurons at E18.5

small cerebellum ( J:156717 )

• E18.5 revealed a nearly complete loss of the midbrain and the cerebellum

decreased dopaminergic neuron number ( J:156717 )

• at E18.5 in the substantia nigra and ventral tegmental area

abnormal serotonergic neuron morphology ( J:156717 )

• at E18.5 a reduction of serotonergic neurons in the raphe nucleus

Allelic Composition	En1^{tm7(cre/ESR1)Alj}/0 Fgf8^tm1.3Mrt/Fgf8^tm2.1Jyhl Gt(ROSA)26Sor^tm1Sor/0
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^{tm7(cre/ESR1)Alj} mutation (1 available); any En1 mutation (33 available)
Fgf8^tm1.3Mrt mutation (1 available); any Fgf8 mutation (21 available)
Fgf8^tm2.1Jyhl mutation (0 available); any Fgf8 mutation (21 available)
Gt(ROSA)26Sor^tm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (997 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:156717 )

N	• unlike mice homozygous for Fgf8^tm2.1Jyhl, mice are normal in size

nervous system

nervous system phenotype ( J:156717 )

N	• unlike mice homozygous for Fgf8^tm2.1Jyhl, the size of the midbrain and cerebellum are normal

Allelic Composition	En1^{tm7(cre/ESR1)Alj}/En1⁺ En2^tm2Alj/En2^tm2Alj Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^{tm7(cre/ESR1)Alj} mutation (1 available); any En1 mutation (33 available)
En2^tm2Alj mutation (0 available); any En2 mutation (104 available)
Gt(ROSA)26Sor^tm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (997 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased rhombomere 1 size ( J:134516 )

• when tamoxifen is administered at E10.5, rhombomere 1 (r1) is reduced in size in mutants at E12.5

• anterior r1 cells contribute to more lateral regions of vermis than normal

decreased midbrain size ( J:134516 )

• when tamoxifen is administered at E10.5, mesencephalon is reduced in size at E12.5 relative to normal

• marked cells in posterior mesencephalon do not expand normally

abnormal tectum morphology ( J:134516 )

• when tamoxifen is administered at E10.5, size of marked domain is smaller than wild-type at E16.5

• in adults, marked domain in tectum is greatly reduced compared to wild-type; marked domain is restricted to remaining region of inferior colliculus

abnormal cerebellum morphology ( J:134516 )

• when tamoxifen is administered at E10.5, size of marked cell population is wider in mutants than in controls at E16.5

• in adults, marked domain is broader than normal

abnormal cerebellum vermis morphology ( J:134516 )

• in adults, vermis is reduced in size

embryo

decreased rhombomere 1 size ( J:134516 )

• when tamoxifen is administered at E10.5, rhombomere 1 (r1) is reduced in size in mutants at E12.5

• anterior r1 cells contribute to more lateral regions of vermis than normal

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