All Phenotypes En1<tm7(cre/ESR1)Alj> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

En1^{tm7(cre/ESR1)Alj}
targeted mutation 7, Alexandra L Joyner
MGI:3528251

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	En1^{tm7(cre/ESR1)Alj}/0 Fgf8^tm1.1Jyhl/Fgf8^tm1.3Mrt	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:4437222
cn2	En1^{tm7(cre/ESR1)Alj}/0 Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:4437223
cn3	En1^{tm7(cre/ESR1)Alj}/0 Fgf8^tm1.3Mrt/Fgf8^tm2.1Jyhl Gt(ROSA)26Sor^tm1Sor/0	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:4437229
cn4	En1^{tm7(cre/ESR1)Alj}/En1⁺ En2^tm2Alj/En2^tm2Alj Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺	involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster	MGI:3789333

Allelic Composition	En1^{tm7(cre/ESR1)Alj}/0 Fgf8^tm1.1Jyhl/Fgf8^tm1.3Mrt
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^{tm7(cre/ESR1)Alj} mutation (1 available); any En1 mutation (34 available)
Fgf8^tm1.1Jyhl mutation (0 available); any Fgf8 mutation (21 available)
Fgf8^tm1.3Mrt mutation (1 available); any Fgf8 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:156717 )

• die at birth

nervous system

abnormal neural tube morphology ( J:156717 )

• a significant increase in the number of dead cells in the mesencephalon and to a less extent in rhombomere of the neural tube of embryos at the 13-somite stage

abnormal rhombomere morphology ( J:156717 )

• a significant increase in the number of dead cells in rhombomere of the neural tube of embryos at the 13-somite stage

abnormal Raphe nucleus morphology ( J:156717 )

• a reduction of serotonergic neurons in raphe nuclei

abnormal midbrain morphology ( J:156717 )

• E18.5 revealed a nearly complete loss of the midbrain and the cerebellum

• a significant increase in the number of dead cells in the mesencephalon at the 13-somite stage

abnormal substantia nigra morphology ( J:156717 )

• depletion of dopaminergic neurons at E18.5

small cerebellum ( J:156717 )

• E18.5 revealed a nearly complete loss of the midbrain and the cerebellum

decreased dopaminergic neuron number ( J:156717 )

• at E18.5 in the substantia nigra and ventral tegmental area

abnormal serotonergic neuron morphology ( J:156717 )

• at E18.5 a reduction of serotonergic neurons in the raphe nucleus

embryo

abnormal neural tube morphology ( J:156717 )

• a significant increase in the number of dead cells in the mesencephalon and to a less extent in rhombomere of the neural tube of embryos at the 13-somite stage

abnormal rhombomere morphology ( J:156717 )

• a significant increase in the number of dead cells in rhombomere of the neural tube of embryos at the 13-somite stage

Allelic Composition	En1^{tm7(cre/ESR1)Alj}/0 Fgf8^tm1.3Mrt/Fgf8^tm1.4Mrt
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^{tm7(cre/ESR1)Alj} mutation (1 available); any En1 mutation (34 available)
Fgf8^tm1.3Mrt mutation (1 available); any Fgf8 mutation (21 available)
Fgf8^tm1.4Mrt mutation (0 available); any Fgf8 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal Raphe nucleus morphology ( J:156717 )

• a reduction of serotonergic neurons in raphe nuclei

abnormal midbrain morphology ( J:156717 )

• E18.5 revealed a nearly complete loss of the midbrain and the cerebellum

abnormal substantia nigra morphology ( J:156717 )

• depletion of dopaminergic neurons at E18.5

small cerebellum ( J:156717 )

• E18.5 revealed a nearly complete loss of the midbrain and the cerebellum

decreased dopaminergic neuron number ( J:156717 )

• at E18.5 in the substantia nigra and ventral tegmental area

abnormal serotonergic neuron morphology ( J:156717 )

• at E18.5 a reduction of serotonergic neurons in the raphe nucleus

Allelic Composition	En1^{tm7(cre/ESR1)Alj}/0 Fgf8^tm1.3Mrt/Fgf8^tm2.1Jyhl Gt(ROSA)26Sor^tm1Sor/0
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^{tm7(cre/ESR1)Alj} mutation (1 available); any En1 mutation (34 available)
Fgf8^tm1.3Mrt mutation (1 available); any Fgf8 mutation (21 available)
Fgf8^tm2.1Jyhl mutation (0 available); any Fgf8 mutation (21 available)
Gt(ROSA)26Sor^tm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

growth/size/body region phenotype ( J:156717 )

N	• unlike mice homozygous for Fgf8^tm2.1Jyhl, mice are normal in size

nervous system

nervous system phenotype ( J:156717 )

N	• unlike mice homozygous for Fgf8^tm2.1Jyhl, the size of the midbrain and cerebellum are normal

Allelic Composition	En1^{tm7(cre/ESR1)Alj}/En1⁺ En2^tm2Alj/En2^tm2Alj Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^{tm7(cre/ESR1)Alj} mutation (1 available); any En1 mutation (34 available)
En2^tm2Alj mutation (0 available); any En2 mutation (104 available)
Gt(ROSA)26Sor^tm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased rhombomere 1 size ( J:134516 )

• when tamoxifen is administered at E10.5, rhombomere 1 (r1) is reduced in size in mutants at E12.5

• anterior r1 cells contribute to more lateral regions of vermis than normal

decreased midbrain size ( J:134516 )

• when tamoxifen is administered at E10.5, mesencephalon is reduced in size at E12.5 relative to normal

• marked cells in posterior mesencephalon do not expand normally

abnormal tectum morphology ( J:134516 )

• when tamoxifen is administered at E10.5, size of marked domain is smaller than wild-type at E16.5

• in adults, marked domain in tectum is greatly reduced compared to wild-type; marked domain is restricted to remaining region of inferior colliculus

abnormal cerebellum morphology ( J:134516 )

• when tamoxifen is administered at E10.5, size of marked cell population is wider in mutants than in controls at E16.5

• in adults, marked domain is broader than normal

abnormal cerebellum vermis morphology ( J:134516 )

• in adults, vermis is reduced in size

embryo

decreased rhombomere 1 size ( J:134516 )

• when tamoxifen is administered at E10.5, rhombomere 1 (r1) is reduced in size in mutants at E12.5

• anterior r1 cells contribute to more lateral regions of vermis than normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24