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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Card14tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3528483
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Card14tm1Lex/Card14tm1Lex B6.129S-Card14tm1Lex MGI:6368820


Genotype
MGI:6368820
hm1
Allelic
Composition		 Card14tm1Lex/Card14tm1Lex
Genetic
Background		 B6.129S-Card14tm1Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card14tm1Lex mutation (1 available); any Card14 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to chemically induced skin inflammation ( J:253409 )
• significantly less thickness of the skin after induced psoriasiform skin inflammation
• reduced numbers of proliferating keratinocytes after induced psoriasiform skin inflammation
• homozygous mice are viable and did not show gross anatomical abnormailites and display normal skin T cell number in both epidermis and dermis

integument
decreased susceptibility to chemically induced skin inflammation ( J:253409 )
• significantly less thickness of the skin after induced psoriasiform skin inflammation
• reduced numbers of proliferating keratinocytes after induced psoriasiform skin inflammation
• homozygous mice are viable and did not show gross anatomical abnormailites and display normal skin T cell number in both epidermis and dermis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory