About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Card14tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3528483
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Card14tm1Lex/Card14tm1Lex B6.129S-Card14tm1Lex MGI:6368820


Genotype
MGI:6368820
hm1
Allelic
Composition		 Card14tm1Lex/Card14tm1Lex
Genetic
Background		 B6.129S-Card14tm1Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Card14tm1Lex mutation (1 available); any Card14 mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to chemically induced skin inflammation ( J:253409 )
• significantly less thickness of the skin after induced psoriasiform skin inflammation
• reduced numbers of proliferating keratinocytes after induced psoriasiform skin inflammation
• homozygous mice are viable and did not show gross anatomical abnormailites and display normal skin T cell number in both epidermis and dermis

integument
decreased susceptibility to chemically induced skin inflammation ( J:253409 )
• significantly less thickness of the skin after induced psoriasiform skin inflammation
• reduced numbers of proliferating keratinocytes after induced psoriasiform skin inflammation
• homozygous mice are viable and did not show gross anatomical abnormailites and display normal skin T cell number in both epidermis and dermis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
06/12/2024
MGI 6.13 		The Jackson Laboratory