Phenotypes associated with this allele

• Allele Symbol: Notch3^tm1Ul
• Allele Name: targeted mutation 1, Urban Lendahl
• Allele ID: MGI:3528497
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Notch3^tm1Ul/Notch3^tm1Ul	Not Specified	MGI:3528980
ht2	Notch3^tm1Ul/Notch3^+	Not Specified	MGI:3528982

Genotype
MGI:3528980

hm1

• Allelic Composition: Notch3^tm1Ul/Notch3^tm1Ul
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:95927 )

N • vascular smooth muscle is normal in the thoracic aorta and common carotid arteries and light and electron microscopic examination detected no abnormalities in the thoracic and abdominal aortas or the carotid, leptomeningeal, and cerebral cortical penetrating arteries

normal phenotype

no abnormal phenotype detected ( J:95927 )

• homozygotes are viable with normal growth, reproduction, and morphology of the brain, heart, lung, eye, and skin

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	CADASIL 1	DOID:0111035	OMIM:125310	J:95927

Genotype
MGI:3528982

ht2

• Allelic Composition: Notch3^tm1Ul/Notch3⁺
• Genetic Background: Not Specified

cardiovascular system

cardiovascular system phenotype ( J:95927 )

N • vascular smooth muscle is normal in the thoracic aorta and common carotid arteries and electron microscopic examination detected no abnormalities in the thoracic and abdominal aortas or the carotid, leptomeningeal, and cerebral cortical penetrating arteries

normal phenotype

no abnormal phenotype detected ( J:95927 )

• heterozygotes are viable with normal growth, reproduction, behavior, and morphology of the brain, heart, lung, eye, and skin

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	CADASIL 1	DOID:0111035	OMIM:125310	J:95927