Phenotypes associated with this allele

• Allele Symbol: Csmd1^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3528558
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Csmd1^tm1Lex/Csmd1^tm1Lex	B6;129S5-Csmd1^tm1Lex/Mmucd	MGI:5485273
hm2	Csmd1^tm1Lex/Csmd1^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6NTac	MGI:5574284

Genotype
MGI:5485273

hm1

• Allelic Composition: Csmd1^tm1Lex/Csmd1^tm1Lex
• Genetic Background: B6;129S5-Csmd1^tm1Lex/Mmucd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:194991 )

N • mice exhibit normal pre-pulse inhibition, social interaction, sucrose preference and d-amphetamine sensitivity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	schizophrenia	DOID:5419	OMIM:181500	J:194991

Genotype
MGI:5574284

hm2

• Allelic Composition: Csmd1^tm1Lex/Csmd1^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6NTac

behavior/neurological

behavior/neurological phenotype ( J:209700 )

N • when normalized to basal startle, mice exhibit normal pre-pulse inhibition

N • mice exhibit normal novel object recognition

abnormal emotion/affect behavior ( J:209700 )

• mice exhibit increased exploratory activity to both familiar and novel objects compared with wild-type mice

behavioral despair ( J:209700 )

• increased immobile time when suspended by the tail

increased anxiety-related response ( J:209700 )

• in an open field and elevated plus maze

increased thigmotaxis ( J:209700 )

decreased startle reflex ( J:209700 )

• elevated startle amplitude to higher acoustic stimuli

abnormal voluntary movement ( J:209700 )

♀ • reduction in non-ambulatory movement in female mice during the dark period

increased locomotor activity ( J:209700 )

♂ • increased horizontal activity in male, but not female, mice during the dark period

growth/size/body

increased body weight ( J:209700 )

• especially in female mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:209700 )

N • mice exhibit normal metabolic rate measurements

improved glucose tolerance ( J:209700 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:209700