Phenotypes associated with this allele

• Allele Symbol: Kmt2a^tm2Sjk
• Allele Name: targeted mutation 2, Stanley J Korsmeyer
• Allele ID: MGI:3528758
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Kmt2a^tm2Sjk/Kmt2a^+ Tg(Mx1-cre)1Cgn/0	involves: 129X1/SvJ * C57BL/6 * CBA	MGI:3529267

Genotype
MGI:3529267

cn1

• Allelic Composition: Kmt2a^tm2Sjk/Kmt2a⁺; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased mortality induced by gamma-irradiation ( J:95914 )

• following pI-pC treatment, gamma-irradiated or ENU treated mutants progress to fatal myeloid disease unlike controls

neoplasm

increased incidence of induced tumors ( J:95914 )

• within 7 months after pI-pC treated mutants were subjected to a sublethal dose of gamma-irradiation or an injection of ENU, 60% of gamma-irradiated and 73% of ENU-treated mutants succumbed to a spectrum of myeloproliferative diseases compared to none of the controls

• pI-pC treated gamma-irradiated mutants had leukemic infiltrates in the liver, lung, and lymph nodes

hematopoietic system

myeloid hyperplasia ( J:95914 )

• following pI-pC treatment, saw an increase in Mac-1+/Gr-1+ myeloid cells in bone marrow, indicating myeloid hyperplasia

• 3 weeks following pI-pC treatment, mutants had an average three-fold increase in granulocyte/macrophage progenitors (GMPs) and a three-fold reduction in the number of common lymphoid progenitors (CLPs) in the bone marrow

• enhanced self-renewal/proliferation of myeloid progenitors (hematopoietic stem cells (HSCs), GMPs and common myeloid progenitors (CMPs)) as indicated by their ability to generate colonies upon serial replating

anemia ( J:95914 )

• following pI-pC treatment, gamma-irradiated or ENU treated mutants developed anemia

abnormal bone marrow cell morphology/development ( J:95914 )

• following pI-pC treatment, gamma-irradiated mutant bone marrow contained pseudo-Gaucher cells, indicating high cell turnover

• following pI-pC treatment, gamma-irradiated and ENU treated mice had a significant increase in either Mac-1+/Gr-1-lo mature monocytes or Mac-1+/Gr-1+ immature myeloid cells and mature neutrophils and decreased B and T cells in the bone marrow

thrombocytopenia ( J:95914 )

• following pI-pC treatment, gamma-irradiated or ENU treated mutants developed thrombocytopenia

increased leukocyte cell number ( J:95914 )

• following pI-pC treatment, gamma-irradiated or ENU treated mutants had increased cell counts of mature monocytes and neutrophils

abnormal spleen morphology ( J:95914 )

• following pI-pC treatment, spleens from gamma-irradiated mutants showed extensive disruption of the splenic architecture by poorly differentiated myeloid cells

• following pI-pC treatment, gamma-irradiated and ENU treated mice had a significant increase in either Mac-1+/Gr-1-lo mature monocytes or Mac-1+/Gr-1+ immature myeloid cells and mature neutrophils and decreased B and T cells in the spleen

enlarged spleen ( J:95914 )

• following pI-pC treatment, gamma-irradiated or ENU treated mutants developed splenomegaly

increased spleen red pulp amount ( J:95914 )

• following pI-pC treatment, spleens from ENU treated mutants demonstrated marked expansion of red-pulp with megakaryoctyes, prominent erythropoiesis, and well-differentiated myelopoiesis

immune system

myeloid hyperplasia ( J:95914 )

• following pI-pC treatment, saw an increase in Mac-1+/Gr-1+ myeloid cells in bone marrow, indicating myeloid hyperplasia

• 3 weeks following pI-pC treatment, mutants had an average three-fold increase in granulocyte/macrophage progenitors (GMPs) and a three-fold reduction in the number of common lymphoid progenitors (CLPs) in the bone marrow

• enhanced self-renewal/proliferation of myeloid progenitors (hematopoietic stem cells (HSCs), GMPs and common myeloid progenitors (CMPs)) as indicated by their ability to generate colonies upon serial replating

increased leukocyte cell number ( J:95914 )

• following pI-pC treatment, gamma-irradiated or ENU treated mutants had increased cell counts of mature monocytes and neutrophils

abnormal spleen morphology ( J:95914 )

• following pI-pC treatment, spleens from gamma-irradiated mutants showed extensive disruption of the splenic architecture by poorly differentiated myeloid cells

• following pI-pC treatment, gamma-irradiated and ENU treated mice had a significant increase in either Mac-1+/Gr-1-lo mature monocytes or Mac-1+/Gr-1+ immature myeloid cells and mature neutrophils and decreased B and T cells in the spleen

enlarged spleen ( J:95914 )

• following pI-pC treatment, gamma-irradiated or ENU treated mutants developed splenomegaly

increased spleen red pulp amount ( J:95914 )

• following pI-pC treatment, spleens from ENU treated mutants demonstrated marked expansion of red-pulp with megakaryoctyes, prominent erythropoiesis, and well-differentiated myelopoiesis

homeostasis/metabolism

increased mortality induced by gamma-irradiation ( J:95914 )

• following pI-pC treatment, gamma-irradiated or ENU treated mutants progress to fatal myeloid disease unlike controls

growth/size/body

enlarged spleen ( J:95914 )

• following pI-pC treatment, gamma-irradiated or ENU treated mutants developed splenomegaly