All Phenotypes Chuk<tm1Lex> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Chuk^tm1Lex/Chuk^tm1Lex Lyz2^tm1(cre)Ifo/Lyz2⁺	involves: 129P2/OlaHsd * 129S/SvEvBrd	MGI:4457384
cn2	Chuk^tm1Lex/Chuk^tm1Lex Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺	involves: 129S/Sv * 129S/SvEvBrd * C57BL/6	MGI:5551391

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired macrophage chemotaxis ( J:159873 )

• macrophages exhibit decreased chemotaxis in response to HMGB1 compared with wild-type cells

• however, chemotaxis response to C5a is normal

impaired neutrophil chemotaxis ( J:159873 )

• neutrophils exhibit impaired chemotaxis in response to HMGB1 compared with wild-type cells

• however, chemotaxis response to TNF-alpha is normal

impaired neutrophil recruitment ( J:159873 )

• following intraperitoneal injection of HMGB1, neutrophil recruitment is decreased compared to in similarly treated wild-type mice

• however, recruitment following injection of TNF-alpha is normal

cellular

impaired macrophage chemotaxis ( J:159873 )

• macrophages exhibit decreased chemotaxis in response to HMGB1 compared with wild-type cells

• however, chemotaxis response to C5a is normal

impaired neutrophil chemotaxis ( J:159873 )

• neutrophils exhibit impaired chemotaxis in response to HMGB1 compared with wild-type cells

• however, chemotaxis response to TNF-alpha is normal

hematopoietic system

impaired macrophage chemotaxis ( J:159873 )

• macrophages exhibit decreased chemotaxis in response to HMGB1 compared with wild-type cells

• however, chemotaxis response to C5a is normal

impaired neutrophil chemotaxis ( J:159873 )

• neutrophils exhibit impaired chemotaxis in response to HMGB1 compared with wild-type cells

• however, chemotaxis response to TNF-alpha is normal

impaired neutrophil recruitment ( J:159873 )

• following intraperitoneal injection of HMGB1, neutrophil recruitment is decreased compared to in similarly treated wild-type mice

• however, recruitment following injection of TNF-alpha is normal

Allelic Composition	Chuk^tm1Lex/Chuk^tm1Lex Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129S/Sv * 129S/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chuk^tm1Lex mutation (1 available); any Chuk mutation (51 available)
Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal fibroblast migration ( J:159873 )

• following tamoxifen-treatment, mouse embryonic fibroblasts (MEFs) exhibit random migration in response to an HMGB1 gradient unlike wild-type cells

decreased fibroblast cell migration ( J:159873 )

• 180 minutes after exposure to HMGB1, tamoxifen-treated MEFs exhibit reduced migration velocity compared with wild-type mice

decreased fibroblast chemotaxis ( J:159873 )

• following tamoxifen-treatment, MEFs exhibit impaired chemotaxis in response to HMGB1 compared with wild-type cells that is not rescued by Nfkb2

• however, chemotaxis in response to PDGF is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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