About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itktm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3528811
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Itktm1Lex/Itktm1Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:3609963


Genotype
MGI:3609963
hm1
Allelic
Composition		 Itktm1Lex/Itktm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itktm1Lex mutation (2 available); any Itk mutation (50 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell number ( J:103485 )
• notable increase in mean percentage of B cells
decreased CD4-positive, alpha-beta T cell number ( J:103485 )
• notable decrease in percentage of CD4+ cells
decreased CD8-positive, alpha-beta T cell number ( J:103485 )
• notable decrease in percentage of CD8+ cells

hematopoietic system
increased B cell number ( J:103485 )
• notable increase in mean percentage of B cells
decreased CD4-positive, alpha-beta T cell number ( J:103485 )
• notable decrease in percentage of CD4+ cells
decreased CD8-positive, alpha-beta T cell number ( J:103485 )
• notable decrease in percentage of CD8+ cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory