Phenotypes associated with this allele

• Allele Symbol: Kcne5^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3528821
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Kcne5^tm1Lex/Y	involves: 129S/SvEv * C57BL/6	MGI:7641771

Genotype
MGI:7641771

ot1

• Allelic Composition: Kcne5^tm1Lex/Y
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal cardiovascular system physiology ( J:283729 )

♂ • mice show 10% shorter ventricular effective refractory period

ventricular tachycardia ( J:283729 )

♂ • one male showed a spontaneously occurring episode of polymorphic ventricular tachycardia VT; this episode could not be terminated by burst pacing, but eventually converted into an atrial arrhythmia with a 2:1 and 3:1 atrioventricular conduction

♂ • mice show increased susceptibility to polymorphic VT induction with a defined pacing protocol followed by 3 extra stimuli

ventricular premature beat ( J:283729 )

♂ • intracardiac ECG shows ventricular premature beats which are followed by postextrasystolic compensatory pauses

♂ • however, mice exhibit normal heart weight, no evidence of cardiac hypertrophy or overt structural defects, and normal noninvasive body surface ECG in anesthetized males at 5 and 8 months of age

abnormal myocardial fiber currents ( J:283729 )

♂ • mean ventricular myocyte voltage-gated potassium current density is increased in the apex and in the subpopulation of septal myocytes that lack fast transient outward current (I[to,f])

♂ • the current increases arise from an apex-specific increase in slow transient outward current-1 (I[Kslow,1], conducted by Kv1.5) and (I[to,f], conducted by Kv4) and an increase in slow transient outward current-2 (I[Kslow,2], conducted by Kv2.1) in both apex and septum