Phenotypes associated with this allele

• Allele Symbol: Nr5a2^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3528835
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr5a2^tm1Lex/Nr5a2^tm1Lex	involves: 129	MGI:3578361
ht2	Nr5a2^tm1Lex/Nr5a2^+	involves: 129	MGI:3578362

Genotype
MGI:3578361

hm1

• Allelic Composition: Nr5a2^tm1Lex/Nr5a2^tm1Lex
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:97625 )

• fewer than expected homozygous embryos are found at E6.5 - E7.0 and no homozygous embryos are found at E7.5 - E9.5

embryonic lethality between implantation and somite formation, incomplete penetrance ( J:97625 )

• fewer than expected homozygous embryos are found at E6.5 - E7.0

embryo

abnormal embryo development ( J:97625 )

• at E6.5 - E7.0, the extraembryonic and embryonic tissues are not readily distinguished from each other

abnormal ectoderm development ( J:97625 )

• the ectoderm is disorganized

decreased embryo size ( J:97625 )

• at E6.5 - E7.0

abnormal proamniotic cavity morphology ( J:97625 )

• the proamniotic cavity is malformed

abnormal visceral endoderm morphology ( J:97625 )

• the visceral endoderm is expanded and the cells are loosely arranged

growth/size/body

decreased embryo size ( J:97625 )

• at E6.5 - E7.0

Genotype
MGI:3578362

ht2

• Allelic Composition: Nr5a2^tm1Lex/Nr5a2⁺
• Genetic Background: involves: 129

mortality/aging

prenatal lethality, incomplete penetrance ( J:97625 )

• the ratio of heterozygous to wild-type pups is only 1.1:1 rather than the expected 2:1